rs1898830, known as -15607A/G and located in the first intron of the TLR2 gene, is associated with an increased risk for shedding and lesion frequency of genital herpes simplex virus type 2 HSV-2 outbreaks.[PMID 17624834]
The risk allele is (G).
Note that the increased risk is not that great; median shedding rate was 16.7% for (G) allele carriers vs 12.0% when it was absent (= risk ratio for a dominant effect of 1.60), and the median lesional rate was 10.4% for (G) carriers vs 5.3% for non-carriers (risk ratio 2.16). [PMID 17624834]
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