|?|| (A;A) (A;G) (G;G) ||28|
Based on a study of 790 individuals from 245 nuclear families (220 families were European Caucasian; 300 of the probands had a diagosis of schizophrenia), the rs2070106(G) allele was overtransmitted to affected offspring.[PMID 18496213]
This actually conflicts with a previous report [PMID 16389193] in which the rs2070106(A) allele was identified (also in Caucasians) in a combined gene association/expression study as associated with schizophrenia.
This is either a case of the "flip-flop" phenomenon [PMID 17273975] in which multilocus effects and variation in interlocus correlations reverse a previously reported association, or perhaps more likely, a false positive.
[PMID 17306456] Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population.
[PMID 17964117] Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
[PMID 18289148] Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.
[PMID 19348671] No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis.
[PMID 22473874] A myelin gene causative of a catatonia-depression syndrome upon aging.
[PMID 23032943] The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives