rs2305764
| Orientation | minus |
| Stabilized | minus |
| Make rs2305764(C;C) |
| Make rs2305764(C;T) |
| Make rs2305764(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 17203024 |
| Gene | MYO9B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2305764 |
| dbSNP (classic) | rs2305764 |
| ClinGen | rs2305764 |
| ebi | rs2305764 |
| HLI | rs2305764 |
| Exac | rs2305764 |
| Gnomad | rs2305764 |
| Varsome | rs2305764 |
| LitVar | rs2305764 |
| Map | rs2305764 |
| PheGenI | rs2305764 |
| Biobank | rs2305764 |
| 1000 genomes | rs2305764 |
| hgdp | rs2305764 |
| ensembl | rs2305764 |
| geneview | rs2305764 |
| scholar | rs2305764 |
| rs2305764 | |
| pharmgkb | rs2305764 |
| gwascentral | rs2305764 |
| openSNP | rs2305764 |
| 23andMe | rs2305764 |
| SNPshot | rs2305764 |
| SNPdbe | rs2305764 |
| MSV3d | rs2305764 |
| GWAS Ctlg | rs2305764 |
| GMAF | 0.4146 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs2305764 is a SNP in the untranslated region of the MYO9B gene that has been associated with celiac disease, and thus gluten intolerance. The risk allele is rs2305764(T) as named in accordance with dbSNP. [PMID 16282976]
However, a 2016 meta-analysis including 8 studies (totaling 2272 cases and 5419 controls) found no significant association for this SNP and celiac disease in Caucasian populations.[PMID 27219348]
[PMID 20096742] Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability
[PMID 17176439] No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population.
[PMID 17584584] MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population.
[PMID 17667713] Analysis of candidate genes on chromosomes 5q and 19p in celiac disease.
[PMID 17944996] The association of MYO9B gene in Italian patients with inflammatory bowel diseases.
[PMID 18361936] Association of MYO9B haplotype with type 1 diabetes.
[PMID 19142207
] MYO9B polymorphisms in multiple sclerosis.
[PMID 20303373] Association analysis of myosin IXB and type 1 diabetes.
[PMID 23368647] Frequency of MYO9B polymorphisms in celiac patients and controls
[PMID 22954106] Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma.
[PMID 27556856] MYO9B gene polymorphisms are associated with the risk of inflammatory bowel diseases.
