rs2491397
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs2491397(C;C) |
| Make rs2491397(C;T) |
| Make rs2491397(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 9 |
| Position | 98442880 |
| Gene | GABBR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2491397 |
| dbSNP (classic) | rs2491397 |
| ClinGen | rs2491397 |
| ebi | rs2491397 |
| HLI | rs2491397 |
| Exac | rs2491397 |
| Gnomad | rs2491397 |
| Varsome | rs2491397 |
| LitVar | rs2491397 |
| Map | rs2491397 |
| PheGenI | rs2491397 |
| Biobank | rs2491397 |
| 1000 genomes | rs2491397 |
| hgdp | rs2491397 |
| ensembl | rs2491397 |
| geneview | rs2491397 |
| scholar | rs2491397 |
| rs2491397 | |
| pharmgkb | rs2491397 |
| gwascentral | rs2491397 |
| openSNP | rs2491397 |
| 23andMe | rs2491397 |
| SNPshot | rs2491397 |
| SNPdbe | rs2491397 |
| MSV3d | rs2491397 |
| GWAS Ctlg | rs2491397 |
| GMAF | 0.3893 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 15759211
] Associated with nicotine Dependence as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.
The risk haplotype varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.[PMID 15759211]
| ClinVar | |
|---|---|
| Risk | rs2491397(T;T) |
| Alt | rs2491397(T;T) |
| Reference | rs2491397(C;C) |
| Significance | Other |
| Disease | Tobacco addiction |
| Variation | info |
| Gene | GABBR2 |
| CLNDBN | Tobacco addiction, susceptibility to |
| Reversed | 0 |
| HGVS | NC_000009.11:g.101205162C\x3d |
| CLNSRC | ClinVar |
| CLNACC | RCV000003495.1, |
