rs28362491
| Orientation | plus |
| Stabilized | plus |
| Make rs28362491(-;-) |
| Make rs28362491(-;ATTG) |
| Make rs28362491(ATTG;ATTG) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 102500998 |
| Gene | LOC105377621, NFKB1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs28362491 |
| dbSNP (classic) | rs28362491 |
| ClinGen | rs28362491 |
| ebi | rs28362491 |
| HLI | rs28362491 |
| Exac | rs28362491 |
| Gnomad | rs28362491 |
| Varsome | rs28362491 |
| LitVar | rs28362491 |
| Map | rs28362491 |
| PheGenI | rs28362491 |
| Biobank | rs28362491 |
| 1000 genomes | rs28362491 |
| hgdp | rs28362491 |
| ensembl | rs28362491 |
| geneview | rs28362491 |
| scholar | rs28362491 |
| rs28362491 | |
| pharmgkb | rs28362491 |
| gwascentral | rs28362491 |
| openSNP | rs28362491 |
| 23andMe | rs28362491 |
| SNPshot | rs28362491 |
| SNPdbe | rs28362491 |
| MSV3d | rs28362491 |
| GWAS Ctlg | rs28362491 |
| Merged from | Rs28720239 |
| GMAF | 0.4472 |
| Max Magnitude | 0 |
rs28362491, also known as the -94 ATTG insertion/deletion polymorphism, is a SNP in the promoter (upstream) region of the NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 gene.
Several studies have seen differences between men and women for this SNP (such as [PMID 24818816
]), and others have seen differences between Asians and Caucasians (such as [PMID 24827594]). Any genotype summaries for this SNP should state which gender and ethnicity any summary is applicable to.
[PMID 19892748] Relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk
[PMID 20836841] Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes
[PMID 22013908] NFKB1 -94 Insertion/Deletion ATTG Polymorphism Contributes to Risk of Systemic Lupus Erythematosus
[PMID 19480714] Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy.
{{PMID Auto |PMID=19734419 |Title=A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. |OA=1 }}
[PMID 21245992] Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.
[PMID 22614238] NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects.
[PMID 23806437] The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer
[PMID 24578542] Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China
[PMID 22742859] NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.
[PMID 22902396] The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility.
[PMID 23299027] The NFKB1 -94 ATTG insertion/deletion polymorphism (rs28362491) contributes to the susceptibility of congenital heart disease in a Chinese population.
[PMID 23357300] Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.
[PMID 23543433] Gene polymorphisms and thyroid function in patients with heart failure.
[PMID 24895544] Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis
[PMID 24971461] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
[PMID 25223483] Effect of functional nuclear factor kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma
[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer
[PMID 25692306] A Functional Insertion/Deletion Polymorphism in the Promoter Region of the NFKB1 Gene Increases the Risk of Papillary Thyroid Carcinoma
[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease
[PMID 26075620] Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population
[PMID 26563375] Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population
[PMID 26885097] Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population.
[PMID 26919710] Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.
[PMID 27488439] Co-stimulatory CD28 and transcription factor NFKB1 gene variants affect idiopathic recurrent miscarriages.
[PMID 27525877] Association of NF-κB1 gene polymorphisms with coronary artery disease in a Han Chinese population.
[PMID 29664665] Genetic Variation in NFKB1 Gene Influences Liver Enzyme Levels in Morbidly Obese Women.
[PMID 30056167] Genetic variation on the NFKB1 genes associates with the outcomes of HCV infection among Chinese Han population.
[PMID 30910844] NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome.
[PMID 31450925] Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand.
[PMID 31826071] Interleukin 28 Polymorphisms and Hepatocellular Carcinoma Development after Direct Acting Antiviral Therapy for Chronic Hepatitis C.
[PMID 32441399] The possible role of NF-κB1 Rs28362491 polymorphism in male fertility of Egyptian population.
[PMID 32671985] Inherited variant in NFκB-1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding.
[PMID 32851488] Nuclear factor NF-κB1 functional promoter polymorphism and its expression conferring the risk of Type 2 diabetes-associated dyslipidemia.
[PMID 31992083] IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study.
