This SNP in the CADM2 gene was found to contribute to life time cannabis use. (p<e-16), beta= 0.070).
Cannabis use is positively associated with a range of other behaviors including alcohol dependence, depression, ADHD, Schizophrenia, bipolar, autism, risk taking and educational attainment and negatively with conscientiousness and subjective well being. This study with 185,000 ever cannabis users discovered 10% of the variance in lifetime cannabis use.
(Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use Biorxiv)
The significant SNPs were (rsID, gene; A1, A2, A1-Freq):