response to chemotherapy http://www.pharmgkb.org/search/annotatedGene/tyms/variant.jsp
(C) more favorable therapeutic response in advanced colorectal cancer and toxicity [PMID 10652619] [PMID 17716232]
(G) allele of this SNP is associated with grade 3 to 4 neutropenia and diarrhea 5-fluorouracil Neutropenia [PMID 16818689]
[PMID 22825513] Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer
[PMID 23652803] Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity and outcome in childhood acute lymphoblastic leukemia
[PMID 23401104] Folate-genetics and colorectal neoplasia: what we know and need to know next
[PMID 24554028] Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
[PMID 33369477] Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.