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From SNPedia

Make rs405509(A;A)
Make rs405509(A;C)
Make rs405509(C;C)
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
dbSNP (classic)rs405509
1000 genomesrs405509
GWAS Ctlgrs405509
Max Magnitude0
? (A;A) (A;C) (C;C) 28

[PMID 17658295] obstructive sleep apnea rs405509

[PMID 19172988OA-icon.png] Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)

Note: the 2016 paper discussing a potential algorithm for Alzheimer's risk based on ApoE promoter polymorphisms, [PMID 27193889OA-icon.png], is considered too preliminary (and based on too few patients) to add to SNPedia in any detail. [PMID 19282863] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension [PMID 19384966] Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene [PMID 19808960OA-icon.png] Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk [PMID 21263195] An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease [PMID 21266206] Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - The Cardiovascular Risk in Young Finns Study [PMID 22028770OA-icon.png] APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk [PMID 16617143OA-icon.png] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data. [PMID 17356695OA-icon.png] Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality. [PMID 17357073OA-icon.png] Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. [PMID 17672902OA-icon.png] Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes. [PMID 18161859OA-icon.png] Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13? [PMID 18254975OA-icon.png] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat. [PMID 18280754OA-icon.png] Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions. [PMID 18813964OA-icon.png] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. [PMID 18823527OA-icon.png] A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. [PMID 19118814OA-icon.png] Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. [PMID 19327864OA-icon.png] SNPit: a federated data integration system for the purpose of functional SNP annotation. [PMID 19406964OA-icon.png] Association of genetic variants with chronic kidney disease in Japanese individuals. [PMID 19408013OA-icon.png] Strategies and issues in the detection of pathway enrichment in genome-wide association studies. [PMID 19541455] Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients. [PMID 19668339OA-icon.png] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. [PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. [PMID 20396431OA-icon.png] Genotyping sleep disorders patients. [PMID 20467002OA-icon.png] Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. [PMID 20723945] The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks. [PMID 21283811OA-icon.png] Associations between APOE variants and metabolic traits and the impact of psychological stress. [PMID 21882290OA-icon.png] Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. [PMID 22430674OA-icon.png] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. [PMID 23021345] Gene-diet interactions on plasma lipid levels in the Inuit population. [PMID 23193196OA-icon.png] Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. [PMID 25085564OA-icon.png] Influence of multiple

Risk rs405509(C;C)
Alt rs405509(C;C)
Reference rs405509(A;A)
Significance Other
Disease Myocardial infarction Coronary artery disease
Variation info
CLNDBN Myocardial infarction Coronary artery disease, severe, susceptibility to
Reversed 1
HGVS NC_000019.9:g.45408836T\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000019463.4, RCV000019464.3,

[PMID 26405973] Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population

[PMID 28346566] Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population.

[PMID 30706571OA-icon.png] A candidate gene study of risk for dementia in older, post-menopausal women: Results from the Women's Health Initiative Memory Study.

[PMID 31426376OA-icon.png] APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer's Disease Risk in a Multiracial Sample.

[PMID 32682842] APOE rs405509 polymorphism and Parkinson's disease risk in the Chinese population.

[PMID 33437219OA-icon.png] Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.