rs4073

Orientation

plus

Stabilized

plus

Make rs4073(A;A)

Make rs4073(A;T)

Make rs4073(T;T)

Reference

GRCh38 38.1/141

Chromosome

4

Position

73740307

Gene

CXCL8

is a	snp
is	mentioned by
dbSNP	rs4073
dbSNP (classic)	rs4073
ClinGen	rs4073
ebi	rs4073
HLI	rs4073
Exac	rs4073
Gnomad	rs4073
Varsome	rs4073
LitVar	rs4073
Map	rs4073
PheGenI	rs4073
Biobank	rs4073
1000 genomes	rs4073
hgdp	rs4073
ensembl	rs4073
geneview	rs4073
scholar	rs4073
google	rs4073
pharmgkb	rs4073
gwascentral	rs4073
openSNP	rs4073
23andMe	rs4073
SNPshot	rs4073
SNPdbe	rs4073
MSV3d	rs4073
GWAS Ctlg	rs4073

GMAF

0.4972

Max Magnitude

0

[PMID 26547713] Polymorphism in the IL-8 Gene Promoter and the Risk of Acne Vulgaris in a Pakistani Population

[PMID 26400525] Association between variants of IL-8 and IL-10 genes, and efficacy of transcatheter arterial chemoembolization and subsequent prognosis in patients with liver cancer

[PMID 26154559] The genetic variant rs4073 A→T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration

[PMID 26135929] A Systematic Review and Meta-Analysis of Three Gene Variants Association with Risk of Prostate Cancer: An Update

[PMID 26047319] Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

[PMID 25521357] Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab

[PMID 25251027] Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels

[PMID 25139485] Single-nucleotide polymorphisms in the vascular endothelial growth factor pathway and outcomes of patients treated with first-line cytotoxic chemotherapy combined with bevacizumab for advanced colorectal cancer

[PMID 25000179] Genetic polymorphisms and sepsis in premature neonates

[PMID 24462138] Association of interleukin 8 with myocardial infarction: Results from the Stockholm Heart Epidemiology Program

[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

[PMID 23831257] Association of IL-8 gene polymorphisms with Non Small Cell Lung Cancer in Tunisia: a case control study

[PMID 23545310] Association between -251A>T polymorphism in the interleukin-8 gene and oral cancer risk: A meta-analysis

[PMID 23251429] Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study.

[PMID 23086128] Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer

[PMID 22788685] Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population

[PMID 22727395] Genetic analysis of the IL8 gene polymorphism (rs4073) in generalized aggressive periodontitis

[PMID 22132000] The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population

[PMID 22000099] Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.

[PMID 21681427] -251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies

[PMID 21649933] A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

[PMID 21637534] Interleukin-8-251T > A, Interleukin-1?-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease

[PMID 21214373] Polymorphisms of CXCL8 and Its Receptor CXCR2 Contribute to the Development and Progression of Childhood IgA Nephropathy.

[PMID 21188496] Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

[PMID 21091348] Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis

[PMID 21042230] Genetic Polymorphisms and Susceptibility to Parenchymal Renal Infection Among Pediatric Patients

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20431935] Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk

[PMID 20015396] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 19994728] Interleukin-8 T-251A polymorphism was associated with positive anti-p53 antibodies in Uzbekistan population.

[PMID 19842025] Association of Interleukin-8 Gene Polymorphisms and Haplotypes with Oral Lichen Planus in a Chinese Population

[PMID 19390575] Lung cancer susceptibility model based on age, family history and genetic variants.

[PMID 19364277] Lack of association of a functional polymorphism in the interleukin 8 gene with susceptibility to periodontitis.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19357773] Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

[PMID 19347053] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18549840] Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.

[PMID 17848170] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.

[PMID 17356794] Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17211588] Lack of association of IL8 gene polymorphisms with familial vesico-ureteral reflux.

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16719905] Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

[PMID 16503988] Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections.

[PMID 28993876] IL-8 Gene Variants and Expression in Childhood Asthma.

[PMID 30186498] Association of cytokine gene polymorphisms with osteoarthritis susceptibility.

[PMID 30275190] IL-8-251T>A (rs4073) Polymorphism Is Associated with Prognosis in Gastric Cancer Patients.

[PMID 30995942] A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.

[PMID 31525531] Association of polymorphisms in IL-8, MMP-1 and MMP-13 with the risk and prognosis of oral and oropharyngeal squamous cell carcinoma.

[PMID 32425678] Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.