rs4355801
| Increased risk with A allele |
| Orientation | plus |
| Stabilized | plus |
| Make rs4355801(A;A) |
| Make rs4355801(A;G) |
| Make rs4355801(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 118911634 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4355801 |
| dbSNP (classic) | rs4355801 |
| ClinGen | rs4355801 |
| ebi | rs4355801 |
| HLI | rs4355801 |
| Exac | rs4355801 |
| Gnomad | rs4355801 |
| Varsome | rs4355801 |
| LitVar | rs4355801 |
| Map | rs4355801 |
| PheGenI | rs4355801 |
| Biobank | rs4355801 |
| 1000 genomes | rs4355801 |
| hgdp | rs4355801 |
| ensembl | rs4355801 |
| geneview | rs4355801 |
| scholar | rs4355801 |
| rs4355801 | |
| pharmgkb | rs4355801 |
| gwascentral | rs4355801 |
| openSNP | rs4355801 |
| 23andMe | rs4355801 |
| SNPshot | rs4355801 |
| SNPdbe | rs4355801 |
| MSV3d | rs4355801 |
| GWAS Ctlg | rs4355801 |
| GMAF | 0.3039 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
news rs4355801, was associated with a 20% increased risk of osteoporosis (significant at P=0.038).
At least one copy of the risk allele (A) of rs4355801 was found in 79% of study participants.
Participants carrying at least one copy of each risk allele -- 22% of the study population -- had a 50% increased risk of osteoporosis, which was significant at P=0.0026, and a 29% increased risk of osteoporotic fractures (significant at P=0.014).
[PMID 18455228
] rs3736228 associated with decreased bone mineral density (p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008).
rs4355801 associated with decreased bone mineral density (p=7.6x10(-10) for lumbar spine and p=3.3x10(-8) for femoral neck) and increased risk of osteoporosis (OR 1.2, 95% CI 1.01-1.42, p=0.038).
The presence of both risk alleles increased the risk of osteoporotic fractures (OR 1.3, 1.08-1.63, p=0.006) and this effect was independent of bone mineral density
| GWAS | |
|---|---|
| SNP | rs4355801 |
| PubMedID | [PMID 18455228]
|
| Condition | Bone mineral density |
| Gene | TNFRSF11B |
| Risk Allele | A |
| pValue | 8.00E-010 |
| OR | 0.09 |
| 95% CI | NR) SD decreas |
[PMID 20146170] Association of LPR5 Polymorphism with Bone Mass Density and Cholesterol Level in Population of Chinese Han
[PMID 20960157] A polymorphism near osteoprotegerin gene confer risk of obesity in Uyghurs
[PMID 22079369] TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women
[PMID 19181680] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
[PMID 19629617] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
[PMID 20072603] Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
[PMID 20534768] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
[PMID 24130145] Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women
[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.
[PMID 25464125] RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes
