rs534870 associates with body fat percentage in individuals of European descent. The body fat percentage decreasing allele of rs534870 was modestly associated with decreased SPRY2 expression in whole blood (a critical regulator of adipose tissue differentiation in mice, [PMID 20410440
]). In contrast with the near-IRS1 locus, there was no association between rs534870 and SPRY2 expression in adipose tissue, brain or liver.
| GWAS snp
|
| PMID
|
[PMID 21706003]
|
| Trait
|
|
| Title
|
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
| Risk Allele
|
A
|
| P-val
|
7E-8
|
| Odds Ratio
|
0.0300 [NR] % decrease
|
[PMID 23708086] NUDT3 rs206936 is associated with body mass index in obese Japanese women.
[PMID 30204480] Machine Learning-Based Method for Obesity Risk Evaluation Using Single-Nucleotide Polymorphisms Derived from Next-Generation Sequencing.
]). In contrast with the near-IRS1 locus, there was no association between rs534870 and SPRY2 expression in adipose tissue, brain or liver.
