Influences appearance gnxp
For the rs642742 SNP (184745.0002), located 326 kb upstream of the KITLG transcription start site, the frequency of the ancestral A allele is at least 92% in West Africans, whereas the frequency of the derived G allele is at least 86% in Europeans and East Asians. Admixture mapping suggested that replacement of AA with GG in the rs642742 SNP may account for a lightening of a person's skin by 6 to 7 melanin units. In comparison, the overall skin reflectance difference between West Africans and Europeans is 30 melanin units.
| OMIM | 611664 |
| Desc | SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 7; SHEP7 |
| Variant | |
| Related | also |
