rs806377(C) together with rs6454674(G) make up a haplotype associated (p=0.008) with higher risk of ADHD. In addition, the haplotype was more associated (p=0.03) with ADHD in males than in females with the risk haplotype. [PMID 18213623]
[PMID 16917946] Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.
[PMID 19016476] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
[PMID 19052543] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
[PMID 19335651] Candidate genes for cannabis use disorders: findings, challenges and directions.
[PMID 19443135] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.
[PMID 21714860] Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (C;C) associated with the highest striatal response is also associated with the longest gaze duration for happy faces.
[PMID 23407780] Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.
[PMID 23422373] CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.