rs894160
| Orientation | minus |
| Stabilized | minus |
| Make rs894160(A;A) |
| Make rs894160(A;G) |
| Make rs894160(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 89668592 |
| Gene | PLIN1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs894160 |
| dbSNP (classic) | rs894160 |
| ClinGen | rs894160 |
| ebi | rs894160 |
| HLI | rs894160 |
| Exac | rs894160 |
| Gnomad | rs894160 |
| Varsome | rs894160 |
| LitVar | rs894160 |
| Map | rs894160 |
| PheGenI | rs894160 |
| Biobank | rs894160 |
| 1000 genomes | rs894160 |
| hgdp | rs894160 |
| ensembl | rs894160 |
| geneview | rs894160 |
| scholar | rs894160 |
| rs894160 | |
| pharmgkb | rs894160 |
| gwascentral | rs894160 |
| openSNP | rs894160 |
| 23andMe | rs894160 |
| SNPshot | rs894160 |
| SNPdbe | rs894160 |
| MSV3d | rs894160 |
| GWAS Ctlg | rs894160 |
| GMAF | 0.3324 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
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"We studied a population-based sample of Caribbean-origin Hispanics (n = 920, aged 45-74 y) living in the Boston area. Obesity measures (waist and hip circumference, BMI) did not differ between GG subjects and carriers of the A allele (GA and AA). In multivariate linear regression models, we found a significant interaction between complex carbohydrate intake as a continuous variable and PLIN 11482 G > A genotype for waist circumference (P = 0.002). By dichotomizing complex carbohydrate intake, we found significantly different effects across PLIN 11482G > A genotypes. When complex carbohydrate intake was <144 g/d, waist circumference was larger in PLIN 11482G > A carriers (P = 0.024). Conversely, when complex carbohydrate intake was >/=144 g/d, waist and hip circumferences were less in PLIN 11482G > A carriers (P < 0.05). These interactions were not found for simple sugars or total carbohydrates. In subjects with higher complex carbohydrate intake, the minor allele was protective against obesity, whereas in subjects with lower carbohydrate intake, the minor allele was associated with increased obesity." [PMID 18806092
]
[PMID 19399648] Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants
[PMID 16836753] Study of the impact of perilipin polymorphisms in a French population.
[PMID 18356850] Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.
[PMID 18812483] Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.
[PMID 19375517] PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
[PMID 19385027] Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.
[PMID 21193293] Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.
[PMID 21392418] Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.
[PMID 23111648] Evaluation of the ENPP1 and PLIN Single Nucleotide Polymorphisms With Type 2 Diabetes in a Taiwanese Population: Evidence for Replication and Gene-Gene Interaction
[PMID 23517113] Association between three genetic variants of the Perilipin Gene (PLIN) and glucose metabolism: results from a replication study among Chinese adults and a meta-analysis
