TRPV1
| is a | gene |
| is | mentioned by |
| Full name | transient receptor potential cation channel, subfamily V, member 1 |
| EntrezGene | 7442 |
| PheGenI | 7442 |
| VariationViewer | 7442 |
| ClinVar | TRPV1 |
| GeneCards | TRPV1 |
| dbSNP | 7442 |
| Diseases | TRPV1 |
| SADR | 7442 |
| HugeNav | 7442 |
| wikipedia | TRPV1 |
| TRPV1 | |
| gopubmed | TRPV1 |
| EVS | TRPV1 |
| HEFalMp | TRPV1 |
| MyGene2 | TRPV1 |
| 23andMe | TRPV1 |
| UniProt | Q8NER1 |
| Ensembl | ENSG00000262304 |
| OMIM | 602076 |
| # SNPs | 10 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs161364 | 0 | 3,574,518 | |
| rs222741 | 0 | 3,605,586 | |
| rs222747 | 0 | 3,589,906 | |
| rs222749 | 0 | 3,592,080 | |
| rs224534 | 0 | 3,583,408 | |
| rs224547 | 0 | 3,571,724 | |
| rs4790521 | 0 | 3,566,472 | |
| rs4790522 | 0 | 3,566,559 | |
| rs8065080 | 0 | 3,577,153 | |
| rs877610 | 0 | 3,572,196 |
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene, located on chromosome 17. The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain, and through "chemical trickery",
the sensation of heat when eating spicy foods such as chili peppers. Wikipedia; [PMID 28044278
]
Studies of TRPV1 variants rarely include large numbers of individuals, nor have any findings been replicated independently, so at this time (2018) any published conclusions should probably be taken with a grain of salt, i.e. as quite preliminary. In addition, be aware that significant linkage between certain TRPV1 SNPs exists, and there is also wide variability in allele frequencies between populations - the major allele in one population may be the minor one in another.
Some of the more notable published conclusions about TRPV1 variants include:
- rs8065080, aka C>T, Val585Ile
- T allele carriers were significantly more sensitive to salt solutions than non-carriers [PMID 23118204]
- Homozygous C allele carriers have higher (pain) tolerance to cold, heat, and pinpricks [PMID 21468319
] - No difference in capsaicin response was noted between alleles of this SNP (or any other TRPV1 SNP) [PMID 17913835]
