rs8065080
| Orientation | plus |
| Stabilized | plus |
| Make rs8065080(C;C) |
| Make rs8065080(C;T) |
| Make rs8065080(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 3577153 |
| Gene | TRPV1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs8065080 |
| dbSNP (classic) | rs8065080 |
| ClinGen | rs8065080 |
| ebi | rs8065080 |
| HLI | rs8065080 |
| Exac | rs8065080 |
| Gnomad | rs8065080 |
| Varsome | rs8065080 |
| LitVar | rs8065080 |
| Map | rs8065080 |
| PheGenI | rs8065080 |
| Biobank | rs8065080 |
| 1000 genomes | rs8065080 |
| hgdp | rs8065080 |
| ensembl | rs8065080 |
| geneview | rs8065080 |
| scholar | rs8065080 |
| rs8065080 | |
| pharmgkb | rs8065080 |
| gwascentral | rs8065080 |
| openSNP | rs8065080 |
| 23andMe | rs8065080 |
| SNPshot | rs8065080 |
| SNPdbe | rs8065080 |
| MSV3d | rs8065080 |
| GWAS Ctlg | rs8065080 |
| GMAF | 0.3893 |
| Max Magnitude | 0 |
rs8065080, also known as c.1191A>G, Ile585Val, I585V, Val585Ile and V585I, represents a common variant in the TRPV1 gene located on chromosome 17. The rs8065080(T) allele encodes the Ile; the rs8065080(C) allele encodes the Val.
The major allele differs between populations; the rs8065080(T) allele is the more common one in Caucasians, Africans, and Hispanics, whereas the rs8065080(C) allele is the more common one in most Asian populations.
Preliminary reports (based on relatively small sample sizes) have indicated the following associations for rs8065080:
- T allele carriers were significantly more sensitive to salt solutions than non-carriers [PMID 23118204]
- Homozygous C allele carriers have higher (pain) tolerance to cold, heat, and pinpricks [PMID 21468319
] - No difference in capsaicin response was noted between alleles of this SNP (or any other TRPV1 SNP) [PMID 17913835]
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 20034385
] Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis
[PMID 21616913] The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
[PMID 21423693] Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.
[PMID 23118204] Genetic Variation in Putative Salt Taste Receptors and Salt Taste Perception in Humans
[PMID 32290310] Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort.
[PMID 32827294] Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine.
