Talk:Rs1800562(A;G)

RR: C282Y heterozygous

Per Dr Eric Lewis,

"Another important point is that we should not dismiss the impact that one single hemochromatosis gene mutation can have upon our health. Even one missense copy of C282Y can lead to a degree of iron overload in some individuals. This scenario can absolutely be an underlying cause of health challenges, symptoms, illness, or disease for a number of people.

Many doctors, lab testing companies, books, and other websites tend to “down-play” the potential health consequences of having only one hemochromatosis gene. You may read or hear that one missense copy is not “clinically relevant”.

To me, this seems to ignore the stories and symptoms of people whose health have been compromised by a moderate level of iron overload. Many individuals from around the world have written me and told me about their health challenges due to high iron… even though they “only” have one gene mutation.

Likewise, I have heard numerous stories from people who did not understand their potential health risk or the implications of storing too much iron. I have seen countless cases in which individuals were told their health was fine, or that it was “all in their head”.

Perhaps worst is when a person is told by a doctor that they have a hemochromatosis gene, but that they do not need to do anything about it, because they only have one mutation. I have even heard of stories where people were discouraged to donate blood, even a single time, even with elevated ferritin!

No citations to peer-reviewed scientific literature are provided on the website you linked to, and, the website sells supplements and related commercial products (books, videos, etc), which is another reason this comment will be removed in time. However, if you wish to provide links on this page to credible peer-reviewed scientific articles on the prevalence of clinical consequences for C282Y heterozygotes, please do and we'll review them.Greg (talk) 14:38, 22 March 2017 (UTC)