rs2302685

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(T;T)	0	common in complete genomics

Make rs2302685(C;C)

Make rs2302685(C;T)

Reference

GRCh38 38.1/141

Chromosome

12

Position

12148964

Gene

LRP6

is a	snp
is	mentioned by
dbSNP	rs2302685
dbSNP (classic)	rs2302685
ClinGen	rs2302685
ebi	rs2302685
HLI	rs2302685
Exac	rs2302685
Gnomad	rs2302685
Varsome	rs2302685
LitVar	rs2302685
Map	rs2302685
PheGenI	rs2302685
Biobank	rs2302685
1000 genomes	rs2302685
hgdp	rs2302685
ensembl	rs2302685
geneview	rs2302685
scholar	rs2302685
google	rs2302685
pharmgkb	rs2302685
gwascentral	rs2302685
openSNP	rs2302685
23andMe	rs2302685
SNPshot	rs2302685
SNPdbe	rs2302685
MSV3d	rs2302685
GWAS Ctlg	rs2302685

GMAF

0.1212

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

rs2302685 increases susceptibility to Alzheimer's disease, late-onset 1.30 times for carriers of the T allele [PMID 17517621]

[PMID 22393312] Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

[PMID 18340469] Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.

[PMID 19667113] A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.

[PMID 20057906] Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.

[PMID 20926594] Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.

[PMID 24906453] The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction