rs31489

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	1.1	Reduced lung cancer risk?
(A;C)	2	1.75-fold reduced risk of developing lung cancer
(C;C)	2	Increased risk for lung cancer and emphysema

Reference

GRCh38 38.1/141

Chromosome

5

Position

1342599

Gene

CLPTM1L

is a	snp
is	mentioned by
dbSNP	rs31489
dbSNP (classic)	rs31489
ClinGen	rs31489
ebi	rs31489
HLI	rs31489
Exac	rs31489
Gnomad	rs31489
Varsome	rs31489
LitVar	rs31489
Map	rs31489
PheGenI	rs31489
Biobank	rs31489
1000 genomes	rs31489
hgdp	rs31489
ensembl	rs31489
geneview	rs31489
scholar	rs31489
google	rs31489
pharmgkb	rs31489
gwascentral	rs31489
openSNP	rs31489
23andMe	rs31489
SNPshot	rs31489
SNPdbe	rs31489
MSV3d	rs31489
GWAS Ctlg	rs31489

GMAF

0.3503

Max Magnitude

2

?	(A;A) (A;C) (C;C)	28

GWAS snp
PMID	[PMID 19836008]
Trait	Lung adenocarcinoma
Title	A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
Risk Allele	C
P-val	2E-10
Odds Ratio	1.12 [1.09-1.16]

[PMID 20142248] Cumulative effect of multiple Loci on genetic susceptibility to familial lung cancer

[PMID 21622582] The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema

[PMID 22404340] Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population

[PMID 22675468] Functional Characterization of CLPTM1L as a Lung Cancer Risk Candidate Gene in the 5p15.33 Locus

[PMID 18978790] Lung cancer susceptibility locus at 5p15.33.

[PMID 24039754] The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer

[PMID 24615522] Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk

[PMID 27517745] Nasopharyngeal carcinoma risk prediction via salivary detection of host and Epstein-Barr virus genetic variants.