| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
normal
|
| (C;T)
|
2
|
0.78x reduced risk for breast cancer
|
| (T;T)
|
2.4
|
0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapy
|
rs3750817 is a SNP in the fibroblast growth factor receptor 2 FGFR2 gene.
A study of 2,166 invasive breast cancer cases concluded that carriers of a rs3750817(T) allele had lower risk for cancer, with an estimated per-minor-allele odds ratio of 0.78. Success with hormone therapy to treat postmenopausal symptoms also correlated with the number of rs3750817(T) alleles.
[PMID 19861516
]
[PMID 20056625] Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer
[PMID 21702935] Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21822685] Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality
[PMID 18285324] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.
| GWAS snp
|
| PMID
|
[PMID 22951594]
|
| Trait
|
Breast cancer
|
| Title
|
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
|
| Risk Allele
|
T
|
| P-val
|
8E-8
|
| Odds Ratio
|
1.22 [NR]
|
[PMID 26070784] Genetic risk variants associated with in situ breast cancer
]
