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From SNPedia

influences social behavior and personality
Geno Mag Summary
(A;A) 2.8 Lack of empathy?
(A;G) 2.8 Lack of empathy?
(G;G) 2.5 Optimistic and empathetic; handle stress well
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs53576
1000 genomesrs53576
GWAS Ctlgrs53576
Max Magnitude2.8

rs53576 is a silent G to A change in the oxytocin receptor (OXTR) gene. Studies have demonstrated that individuals with the G allele are more empathetic, feel less lonely, employ more sensitive parenting techniques, and have lower rates of autism (discussed in [PMID 20724662OA-icon.png])

The blog Not Exactly Rocket Science discusses that Americans with (G;G) tend to be more sensitive parents, more empathetic and less lonely than those with an ‘A’. In a Korean population people with (G;G) were less likely to seek support from their peers.

[PMID 20724662OA-icon.png] Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking.

[PMID 19934046OA-icon.png] Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. In brief, people with the G;G genotype were better able to discern the emotional state of others than those who carried the A-allele (blog summary found here). The study encompassed 192 participants of both sexes and mixed ethnicities. The study subjects underwent a number of tests to determine their level of empathy and stress reactivity. They found that G;G individuals performed significantly better on the behavioral measure of empathy and were 22.7% less likely to make a mistake on the "Reading the Mind in the Eyes Test" (RMET) (a behavioural measure of empathic accuracy) than A;A/A;G individuals (P = 0.005). Similarly, G;G individuals reported higher levels of dispositional empathy than A;A/A;G individuals: mean (SE) = 3.69 (0.06) and 3.53 (0.04) for G;G and A;A/A;G, respectively (P = 0.025), and were less affected by stress (as measured by their heart rates): mean (SE) = 72.1 (0.54) and 78.4 (1.19) for G;G and A;A/A;G, respectively.

[PMID 19376182] Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects.

[PMID 19015103OA-icon.png] This study examined the association between the OXTR gene and parenting. A total of 176 mothers of toddlers were included in the study. After controlling for marital discord, depression, and education status, rs53576 was found to significantly correlate with parenting, with the G;G genotype being associated with a significantly more sensitive parenting style than A;A or A;G genotypes. However, they concluded that the major factor influencing parenting was the maternal education level.

[PMID 22069391OA-icon.png] Forty-five female subjects (17 twin pairs and 11 twins without their sibling) were genotyped and tested for their ability to hear and understand conversations in noisy environments. Participants with the G;G genotype reported less difficulty hearing and understanding (difficulty hearing total score [Mean (SD)], 9.2 (4.2)) than participants with A;A/A;G genotypes (13.9 (3.8); p < 0.001). Even after adjusting for age, the relationship between genotype and difficulty hearing scores was still significant (p = 0.003).

[PMID 22123970OA-icon.png] Two hundred three healthy German male university students (mean age 23.2 y, SD 2.9 y) were subjected to a mock interview and their saliva cortisol levels were tested before and at a number of time points after the interview. Half of the participants were told to bring a female friend as social support, whereas the other half came alone to the interview. The authors found that subjects carrying the G allele (G;G or A;G genotypes) had significantly lower cortisol responses to stress when they had social support (P < 0.01). Conversely, there were no differences in cortisol levels in subjects with the A;A genotype receiving or not receiving social support (P = 0.46). Moreover, there was a trend (P = 0.08) for people with the A;A genotype to display higher levels of cortisol throughout the session than G carriers (no differences between the genotypes were observed at baseline).

23andMe blog discusses the snp.

blogs.scientificamerican discusses the snp.

[PMID 20647384OA-icon.png] In this study, 345 healthy subjects were examined by multimodal neuroimaging techniques to identify structural and functional alterations in OXTR risk allele carriers and their link to temperament. The authors found that there was a significant association between the different rs53576 genotypes and grey matter volume in the hypothalamus, with the hypothalamus volume being significantly larger in G;G carriers than in A;A carriers (P = 0.012). Moreover, they investigated the relationship between rs53576 and reward dependence (RD) using the Tridimensional Personality Questionnaire, and found that the G;G, G;A, and A;A genotypes were associated with the highest, intermediate, and lowest RD values, respectively (G;G vs. A;A, p=0.02; A;G vs. A;A, p=0.07). Lastly, they also demonstrated that rs53576 is associated with amygdala activation, with the A;A genotype being associated with a significant reduction in activation compared to the G;G genotype (p=0.036); and with the functional relationship between the amygdala and the hypothalamus, with A;A carrier having a significantly increased functional correlation (p=0.036). The authors concluded that there is likely a neural mechanism linking both structural and neural signalling alterations in the oxytocinergic system to individual differences in emotional reactivity and prosocial temperament.

[PMID 17383819OA-icon.png] Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. This study found that there is no association between rs53576 variants and the risk of autism in Caucasian children and adolescents.

[PMID 22084107OA-icon.png] Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition


[PMID 22499788OA-icon.png] Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality.

[PMID 22357335] The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy

[PMID 22763666OA-icon.png] The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype

[PMID 15992526] Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.

[PMID 18687882] Genetic correlates of adult attachment style.

[PMID 19515497] Oxytocin receptor polymorphisms and adult attachment style in patients with depression.

[PMID 20347913] Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD.

[PMID 20585395OA-icon.png] No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences

[PMID 21896752OA-icon.png] Oxytocin receptor gene (OXTR) is related to psychological resources.

[PMID 22372486] The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression.

[PMID 22487732] Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.

[PMID 22563705OA-icon.png] Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes.

[PMID 22580735] Breastfeeding and its relation to maternal sensitivity and infant attachment.

[PMID 23089921OA-icon.png] Common oxytocin receptor gene polymorphisms and the risk for preterm birth

[PMID 23284802OA-icon.png] Association between Oxytocin Receptor Gene Polymorphisms and Self-Rated 'Empathic Concern' in Schizophrenia

[PMID 23470776] Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress

[PMID 23684879] Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects

[PMID 24295535OA-icon.png] Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others

[PMID 24621832OA-icon.png] Oxytocin receptor gene polymorphism, perceived social support, and psychological symptoms in maltreated adolescents

[PMID 22809402] Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans--an exploratory study.

[PMID 22939719] Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor.

[PMID 23708061] Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament.

[PMID 22651577] Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study

[PMID 24814480OA-icon.png] Social cognition, face processing, and oxytocin receptor single nucleotide polymorphisms in typically developing children

[PMID 25003328OA-icon.png] Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort

[PMID 25001970] Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits-A SPECT study

[PMID 25564674OA-icon.png] Distress of ostracism: Oxytocin receptor gene polymorphism confers sensitivity to social exclusion

[PMID 25637390] Oxytocin receptor gene and racial ingroup bias in empathy-related brain activity

[PMID 25680993OA-icon.png] Interaction between oxytocin receptor polymorphism and interdependent culture values on human empathy

[PMID 25935637] The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576)

[PMID 24621820OA-icon.png] Personality, behavior and environmental features associated with OXTR genetic variants in British mothers

[PMID 25287464] Empathy, target distress, and neurohormone genes interact to predict aggression for others-even without provocation

[PMID 25450139OA-icon.png] Preliminary evidence for the interaction of the oxytocin receptor gene (oxtr) and face processing in differentiating prenatal smoking patterns

[PMID 26175754OA-icon.png] DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women

[PMID 26174935] Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder

[PMID 26178189OA-icon.png] A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans

[PMID 26389606OA-icon.png] Genetic Moderation of Stability in Attachment Security From Early Childhood to Age 18 Years: A Replication Study

[PMID 26444016OA-icon.png] Polymorphism of the Oxytocin Receptor Gene Modulates Behavioral and Attitudinal Trust among Men but Not Women

[PMID 26787430OA-icon.png] Oxytocin receptor gene variation predicts subjective responses to MDMA.

[PMID 28715704OA-icon.png] Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

[PMID 23562248] The association between the oxytocin receptor gene (OXTR) and hypnotizability.

[PMID 29860184] Attempted suicide and oxytocin-related gene polymorphisms.

[PMID 29890447] Effect of the interaction between oxytocin receptor gene polymorphism (rs53576) and stressful life events on aggression in Chinese Han adolescents.

[PMID 29927293OA-icon.png] Oxytocin-related single-nucleotide polymorphisms, family environment, and psychopathic traits.

[PMID 32957930OA-icon.png] Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis.