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PON2

From SNPedia

is agene
is mentioned by
Full nameparaoxonase 2
EntrezGene5445
PheGenI5445
VariationViewer5445
ClinVarPON2
GeneCardsPON2
dbSNP5445
SADR5445
HugeNav5445
wikipediaPON2
googlePON2
gopubmedPON2
EVSPON2
HEFalMpPON2
MyGene2PON2
23andMePON2
UniProtQ15165
EnsemblENSG00000105854
OMIM602447
# SNPs15
 Max MagnitudeChromosome positionSummary
rs1198143395,425,028
rs1198248695,426,286
rs12026095,411,704
rs1270479595,424,695
rs13306702095,404,734
rs1787608895,424,695
rs17876142095,411,704
rs17876183095,434,956
rs17876205095,403,792
rs472918995,428,647
rs695434595,405,463
rs7493095,405,463
rs778584695,404,529
rs778640195,404,689
rs98753995,407,680

Like PON1, variations in PON2, the paraoxonase 2 gene, have been linked to several medical conditions.

Paraoxonases are esterases, a complex family of enzymes involved in breaking down chemicals including several types of pesticides and pharmaceutical drugs, and also involved in protecting both high- and low-density lipoproteins from oxidation. Individuals with less paraoxonase activity appear to be more susceptible to Heart disease, pesticide poisoning, atherosclerosis and Diabetes.

[PMID 16822964] rs12704795, originally known as rs17876088 is associated with ALS (Lou Gehrig's). This variation occurs in the PON2 gene, which encodes a protein involved in the detoxification of certain environmental toxins.

[PMID 9329371] reports that a common variation present at amino acid 148 of the PON2 protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).

[PMID 19840942] reports that inheriting the Cys form encoded by PON2 rs7493 results in impaired lactonase activity.