Like PON1, variations in PON2, the paraoxonase 2 gene, have been linked to several medical conditions.
Paraoxonases are esterases, a complex family of enzymes involved in breaking down chemicals including several types of pesticides and pharmaceutical drugs, and also involved in protecting both high- and low-density lipoproteins from oxidation. Individuals with less paraoxonase activity appear to be more susceptible to Heart disease, pesticide poisoning, atherosclerosis and Diabetes.
[PMID 16822964] rs12704795, originally known as rs17876088 is associated with ALS (Lou Gehrig's). This variation occurs in the PON2 gene, which encodes a protein involved in the detoxification of certain environmental toxins.