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rs12026

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in clinvar
Make rs12026(C;G)
Make rs12026(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position95411704
GenePON2
is asnp
is mentioned by
dbSNPrs12026
ebirs12026
HLIrs12026
Exacrs12026
Varsomers12026
Maprs12026
PheGenIrs12026
hapmaprs12026
1000 genomesrs12026
hgdprs12026
ensemblrs12026
gopubmedrs12026
geneviewrs12026
scholarrs12026
googlers12026
pharmgkbrs12026
gwascentralrs12026
openSNPrs12026
23andMers12026
23andMe allrs12026
SNP Nexus

SNPshotrs12026
SNPdbers12026
MSV3drs12026
GWAS Ctlgrs12026
Merged fromRs17876142
GMAF0.2548
Max Magnitude0
? (C;C) (C;G) (G;G) 28
[PMID 9329371] reports that one or two copies of a common variation (glycine replacing alanine) present at amino acid 148 of the PON2 protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).
Neighborrs17876142
Distance1
OMIM602447
Desc
Variant0002
Relatedalso


ClinVar
Risk rs12026(G;G)
Alt rs12026(G;G)
Reference rs12026(C;C)
Significance Non-pathogenic
Disease PARAOXONASE 2 POLYMORPHISM
Variation info
Gene PON2
CLNDBN PARAOXONASE 2 POLYMORPHISM
Reversed 1
HGVS NC_000007.13:g.95041016G>C
CLNSRC OMIM Allelic Variant
CLNACC RCV000007501.2,



[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.


[PMID 21223581OA-icon.png] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.


GET Evidence
PON2-A148G
aa_change Ala148Gly
aa_change_short A148G
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.245864
summary



[PMID 23327886] Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.


[PMID 24100645] Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy


[PMID 24148949] [Association between single nucleotide polymorphisms of PON2 gene and susceptibility to occupational noise-induced deafness among Chinese Han population exposed to high noise levels]