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rs10033464

From SNPedia

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Geno Mag Summary
(G;G) 1.9 0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.
(G;T) 3 1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.
(T;T) 3 1.4x increased risk of Atrial Fibrillation and cardioembolic stroke
ReferenceGRCh38 38.1/141
Chromosome4
Position110799605
is asnp
is mentioned by
dbSNPrs10033464
ebirs10033464
HLIrs10033464
Exacrs10033464
Varsomers10033464
Maprs10033464
PheGenIrs10033464
hapmaprs10033464
1000 genomesrs10033464
hgdprs10033464
ensemblrs10033464
gopubmedrs10033464
geneviewrs10033464
scholarrs10033464
googlers10033464
pharmgkbrs10033464
gwascentralrs10033464
openSNPrs10033464
23andMers10033464
23andMe allrs10033464
SNP Nexus

SNPshotrs10033464
SNPdbers10033464
MSV3drs10033464
GWAS Ctlgrs10033464
GMAF0.1635
Max Magnitude3
? (G;G) (G;T) (T;T) 28
Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[PMID 17603472]

[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4).

[PMID 19141561OA-icon.png] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.

GWAS
SNP rs10033464
PubMedID [PMID 17603472]
Condition Atrial fibrillation/atrial flutter
Gene PITX2,ENPEP
Risk Allele T
pValue 7.00E-011
OR 1.39
95% CI 1.26-1.53


OMIM611494
DescATRIAL FIBRILLATION, FAMILIAL, 5; ATFB5
Variant
Relatedalso
[PMID 21414601OA-icon.png] Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting


[PMID 21760908OA-icon.png] Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population

[PMID 20031626OA-icon.png] Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

[PMID 20170812] Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.

[PMID 20173747OA-icon.png] Common variants in KCNN3 are associated with lone atrial fibrillation.

[PMID 20606429] Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.

[PMID 20671249] The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.

[PMID 20676228OA-icon.png] Lone AF - etiologic factors and genetic insights into pathophysiolgy.


GET Evidence
rs10033464
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.820312
summary



[PMID 22726630OA-icon.png] Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.


[PMID 22818067OA-icon.png] Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.


[PMID 23178686OA-icon.png] Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation.


[PMID 23428961OA-icon.png] Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.


[PMID 24065534OA-icon.png] Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis


[PMID 25684755] Common Genetic Variants and Response to Atrial Fibrillation Ablation


[PMID 26005361OA-icon.png] Association of common variations on chromosome 4q25 and left atrial volume in patients with atrial fibrillation