Rs1045485
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1045485 |
| hapmap | rs1045485 |
| hgdp | rs1045485 |
| ensembl | rs1045485 |
| gopubmed | rs1045485 |
| scholar | rs1045485 |
| rs1045485 | |
| pharmgkb | rs1045485 |
| hgvbaseg2p | rs1045485 |
| medrefsnp | rs1045485 |
| 23andMe | rs1045485 |
| SNP Nexus |
| Gene | CASP8 |
| Chromosome | 2 |
| Orientation | plus |
| Position | 201857833 |
| Genotype | Effect |
|---|---|
| rs1045485(C;C)* | ? |
| rs1045485(C;G)* | ? |
| rs1045485(G;G)* | ? |
rs1045485, also known as D302H, is a SNP in the caspase-8 CASP8 gene.
[PMID 15601643, PMID 17018785, PMID 17293864] Several large studies indicate that the (C) allele of this SNP, located in exon 10 of the CASP8 gene, may reduce the risk of breast cancer in a dose dependent manner. The odds ratio is 0.89 for (C;G) and 0.74 for (C;C) carriers. [PMID 17293864]
[PMID 19318553] A 4-SNP haplotype including rs1045485 was significantly associated with breast cancer in a large European study (3,000+ cases, 3,000+ controls), with a per allele odds ratio of 1.3 (CI:1.12-1.49).
[PMID 19074885] chronic lymphocytic leukemia rs2266690 rs17028658 rs4505265 rs1045485 rs2779251 rs3136687
| Neighbor | rs17860424 |
| Distance | 7958 |
| ? | (C;C) (C;G) (G;G) |
|---|---|
|
| |
[PMID 18431743] showed no association with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin ovarian cancer
[PMID 18362937] No association seen between rs1045485 and colorectal cancer in 4,000 UK cases.
[PMID 19843670] Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer
[PMID 20033885] Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma
