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From SNPedia

Geno Mag Summary
(C;C) 1 increased risk of cannabis dependence, lower (normal) cancer risk
(C;T) 2 Slower metaboliser for some drugs
(T;T) 3 altered drug metabolism and bioavailability; moderately increased risk for certain cancers
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs1045642
23andMe allrs1045642
SNP Nexus

GWAS Ctlgrs1045642
Max Magnitude3
? (C;C) (C;T) (T;T) 28
rs1045642, also known as C3435T, is a SNP located in the ABCB1 gene. It is often studied in conjunction with rs2032582. C3435T has been mentioned by:
  • [PMID 17185560] A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity (for example, to verapamil)
  • [PMID 17190370] (R)-lansoprazole (Prevacid) concentrations are significantly increased in CYP2C19 extensive metabolizers with ABCB1 C3435T C allele.
  • [PMID 15536457] In a Korean population, plasma concentrations of fexofenadine (Allegra) were 17% lower in 2677AA/3435CC subjects and 47% higher in the 2677TT/3435TT subjects compared to 2677GG/3435CC subjects.
  • [PMID 11994059OA-icon.png] In contrast, in this study no association was observed between the C3435T polymorphism and fexofenadine plasma or urine concentrations in a German Caucasian population.
  • [PMID 20491876] A meta-analysis including 9 case-control studies (totaling ~2,500 patients) found no association between rs1045642 and epilepsy risk

A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454OA-icon.png]

[PMID 19437139] ABCB1 single nucleotide polymorphisms in the Brazilian population

[PMID 20664232] Antidepressants and ABCB1 Gene C3435T Functional Polymorphism: A Naturalistic Study

[PMID 20944127] Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer

[PMID 21247447OA-icon.png] CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population


[PMID 21902503] ABCB1 polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia

[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

[PMID 22110582OA-icon.png] Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients

[PMID 22120734] Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia

[PMID 21705081] Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma

[PMID 22176633] ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

[PMID 21806386] Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients

[PMID 22416375] [Genetic performance criteria valproate in patients with epilepsy]

[PMID 22630058] ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese Epileptic Patients

[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.

[PMID 15805193OA-icon.png] Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.

[PMID 16999857OA-icon.png] ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients.

[PMID 17146660] Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.

[PMID 17366837OA-icon.png] Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.

[PMID 17548681] MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.

[PMID 17674045] No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.

[PMID 17913323] ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

[PMID 18182569OA-icon.png] Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.

[PMID 18213362OA-icon.png] Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array.

[PMID 18285546OA-icon.png] A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.

[PMID 18518969OA-icon.png] Association of ABCB1 genetic variants with renal function in Africans and in Caucasians.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18725235OA-icon.png] Bidirectional translational research: Progress in understanding addictive diseases.

[PMID 18784455OA-icon.png] The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.

[PMID 18812236] No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.

[PMID 18854777OA-icon.png] Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 19155191OA-icon.png] Opiate and cocaine addiction: from bench to clinic and back to the bench.

[PMID 19193698OA-icon.png] Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.

[PMID 19197249OA-icon.png] Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

[PMID 19285141OA-icon.png] Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.

[PMID 19373654] ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.

[PMID 19694740OA-icon.png] No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

[PMID 19740399OA-icon.png] Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant.

[PMID 19930591OA-icon.png] Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

[PMID 20170205] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I.

[PMID 20214406] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.

[PMID 20354687OA-icon.png] Explaining variability in ciclosporin exposure in adult kidney transplant recipients.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20533057OA-icon.png] ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.

[PMID 20859246] ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.

[PMID 21102498] Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21185600] Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia.

[PMID 21332314] Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer.

[PMID 21364332] Ultra-resistant schizophrenia is not associated with the multidrug-resistant transporter 1 (MDR1) gene rs1045642 variant.

[PMID 21468756] The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.

[PMID 21544031] Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity.

[PMID 21553324] Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome.

[PMID 21827404] The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.

[PMID 21840870] Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.

[PMID 21896346] Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.

[PMID 22112610OA-icon.png] Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study.

[PMID 22134106] ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.

[PMID 22135187] Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans.

[PMID 22136368] Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.

[PMID 22306099] Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.

[PMID 22311042] MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.

[PMID 22396794OA-icon.png] A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.

[PMID 22434582] Neither P-gp SNP variants, P-gp expression nor functional P-gp activity predicts MDR in a preliminary study of plasma cell myeloma.

[PMID 22569204OA-icon.png] PharmGKB summary: phenytoin pathway.

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.580405

[PMID 22672924] Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas

[PMID 23188198OA-icon.png] ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

[PMID 23279665] ABCB1/MDR1 gene polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia

[PMID 23546964] Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant

[PMID 23093106] Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis

[PMID 23786015] [Pharmacogenetic criteria drug-resistence epilepsy]

[PMID 23803057] Gene Polymorphisms of OPRM1 A118G and ABCB1 C3435T May Influence Opioid Requirements in Chinese Patients with Cancer Pain

[PMID 23372834OA-icon.png] ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort

[PMID 23926124] A Functional Common Polymorphism of the ABCB1 Gene Is Associated With Chronic Kidney Disease and Hypertension in Chinese

[PMID 24070710] Association between MDR1 C3435T polymorphism and risk of breast cancer

[PMID 24086514OA-icon.png] Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study

[PMID 23917080OA-icon.png] ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

[PMID 24380367OA-icon.png] Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme

[PMID 24469730] Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population

[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage

[PMID 24577069] Implication of P-Glycoprotein in Formation of Depression-Prone Personality: Association Study between the C3435T MDR1 Gene Polymorphism and Interpersonal Sensitivity

[PMID 22859359] ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis.

[PMID 22875622OA-icon.png] Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy.

[PMID 23107763] Host genetic risk factors for community-acquired pneumonia.

[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

[PMID 23133441OA-icon.png] ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients.

[PMID 23443032OA-icon.png] Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.

[PMID 23504525] Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer susceptibility : a meta-analysis based on 11,339 subjects.

[PMID 23647060] Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 23896815OA-icon.png] Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury

[PMID 24915124] Common genetic variants in the glucocorticoid receptor and the 11β-Hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission

[PMID 24918524] Association study between the MDR1 gene and clinical characteristics in schizophrenia

[PMID 23996099] ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients

[PMID 25007187] Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia

[PMID 25217066] Relationship Between ABCB1 Polymorphisms, Thromboelastography and Risk of Bleeding Events in Clopidogrel-Treated Patients With ST-Elevation Myocardial Infarction

[PMID 25452814OA-icon.png] Risk factors for clopidogrel resistance in patients with ischemic cerebral infarction and the correlation with ABCB1 gene rs1045642 polymorphism

[PMID 26109419] Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study

[PMID 25355168OA-icon.png] Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms

[PMID 25520092] Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia

[PMID 26336903] Impact of MTHFR rs1801133, MTHFR rs1801131 and ABCB1 rs1045642 polymorphisms with increased susceptibility of rheumatoid arthritis in the West Algerian population: A case-control study

[PMID 26189305] ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population

[PMID 26457621] Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease

[PMID 26489634] Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients

[PMID 26535684] VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head

[PMID 25853335] Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.

[PMID 27534401] Associations between MDR1 C3435T polymorphism and drug-resistant epilepsy in the Polish population.

[PMID 27600024] Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.


Risk rs1045642(C;C)
Alt rs1045642(C;C)
Reference rs1045642(T;T)
Significance Drug-response
Disease ondansetron response - Efficacy oxycodone response - Dosage methadone response - Dosage methotrexate response - Toxicity/ADR nevirapine response - Toxicity/ADR tramadol response - Dosage morphine response - Dosage digoxin response - Other opioids response - Dosage fentanyl response - Dosage
Variation info
Gene ABCB1
CLNDBN ondansetron response - Efficacy oxycodone response - Dosage methadone response - Dosage methotrexate response - Toxicity/ADR nevirapine response - Toxicity/ADR tramadol response - Dosage morphine response - Dosage digoxin response - Other opioids response - Dosage fentanyl response - Dosage
Reversed 1
HGVS NC_000007.13:g.87138645A>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211142.1, RCV000211170.1, RCV000211173.1, RCV000211266.1, RCV000211276.1, RCV000211291.1, RCV000211300.1, RCV000211363.1, RCV000211388.1, RCV000211389.1,