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rs1050283

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) increased risk for Alzheimer's
(C;T) increased risk for Alzheimer's
(T;T) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome12
Position10159690
GeneOLR1
is asnp
is mentioned by
dbSNPrs1050283
ebirs1050283
HLIrs1050283
Exacrs1050283
Varsomers1050283
Maprs1050283
PheGenIrs1050283
hapmaprs1050283
1000 genomesrs1050283
hgdprs1050283
ensemblrs1050283
gopubmedrs1050283
geneviewrs1050283
scholarrs1050283
googlers1050283
pharmgkbrs1050283
gwascentralrs1050283
openSNPrs1050283
23andMers1050283
23andMe allrs1050283
SNP Nexus

SNPshotrs1050283
SNPdbers1050283
MSV3drs1050283
GWAS Ctlgrs1050283
GMAF0.3466
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs1050283, a SNP also known as +1073, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 gene, which is also known as the LOX-1 gene.

The rs1050283(C) allele has been associated with increased risk for Alzheimer's disease in several studies of ~200 Southern Italian Alzheimer patients. The risk is independent of ApoE status, and may also be defined by haplotypes including one or both of neighboring SNPs rs12316150 and rs669.[PMID 15860461, PMID 18191876]

Neighborrs12316150
Distance2


[PMID 21709374] Role of OLR1 and Its Regulating hsa-miR369-3p in Alzheimer's Disease: Genetics and Expression Analysis


[PMID 18384690OA-icon.png] Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.


[PMID 20615707] Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.


[PMID 20682755OA-icon.png] A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.