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rs1057910(C;C)

From SNPedia

CYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugs
Is agenotype
ofrs1057910
GeneCYP2C9
Chromosome10
Position94,981,296
Merged fromRs17847042
mentionedby
Magnitude4
ReputeBad
Geno Mag Summary
(A;A) 0.1 normal; no effect on warfarin metabolism
(A;C) 2.5 CYP2C9*3 carrier; average 40% reduction in warfarin metabolism
(C;C) 4 CYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugs

  • rs1057910(C;C) genotypes may clear drugs like celecoxib (trade name Celebrex) twice as slowly as rs1057910(A;A) genotypes; the rs1057910(A;C) genotypes are in-between clearance rates. Lower clearance rates will lead to higher internal concentrations of the drug. It is not clear whether this could lead to increased efficacy and/or increased side effects. [PMID 12893985]
  • rs1057910(C;C) genotypes are poor metabolizers of glipizide, a second generation sulfonylurea drug structurally similar to tolbutamide and also used as an oral hypoglycemic agent. [PMID 10208645]
  • rs1057910(C;C) genotypes are poor metabolizers of warfarin, and therefore unusually sensitive. [PMID 9352571]