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rs11178997

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0
Make rs11178997(A;A)
Make rs11178997(A;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position71938373
GeneTPH2
is asnp
is mentioned by
dbSNPrs11178997
ebirs11178997
HLIrs11178997
Exacrs11178997
Varsomers11178997
Maprs11178997
PheGenIrs11178997
hapmaprs11178997
1000 genomesrs11178997
hgdprs11178997
ensemblrs11178997
gopubmedrs11178997
geneviewrs11178997
scholarrs11178997
googlers11178997
pharmgkbrs11178997
gwascentralrs11178997
openSNPrs11178997
23andMers11178997
23andMe allrs11178997
SNP Nexus

SNPshotrs11178997
SNPdbers11178997
MSV3drs11178997
GWAS Ctlgrs11178997
GMAF0.1446
Max Magnitude0
rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission

paper Association with and bipolar disorder in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001

[PMID 17568567] rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain.

paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors for major depression

pdf paper associated with bipolar disorder

[PMID 17905754] Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for bipolar disorder in a study of 883 Russian patients.

Neighborrs4570625
Distance230
OMIM143465
DescATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
Variant
Relatedalso
OMIM607478
DescTRYPTOPHAN HYDROXYLASE 2; TPH2
Variant
Relatedalso


[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals

OMIM125480
Desc
Variant
Relatedalso
OMIM613003
Desc
Variant
Relatedalso


[PMID 22483952] Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms

[PMID 16116490] Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

[PMID 17015812] Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.

[PMID 18782386OA-icon.png] Tryptophan hydroxylase 2 gene and alcohol use among college students.

[PMID 18797398] Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.

[PMID 20126463OA-icon.png] Alternative splicing and extensive RNA editing of human TPH2 transcripts.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 22392150] Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.


[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.


[PMID 25014617] TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors