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rs117767867

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
(C;T) 1.5 1.25x risk for type 2 diabetes
(T;T) 1.5 1.5x risk for type 2 diabetes
ReferenceGRCh38 38.1/141
Chromosome17
Position7043011
GeneSLC16A11
is asnp
is mentioned by
dbSNPrs117767867
ebirs117767867
HLIrs117767867
Exacrs117767867
Varsomers117767867
Maprs117767867
PheGenIrs117767867
hapmaprs117767867
1000 genomesrs117767867
hgdprs117767867
ensemblrs117767867
gopubmedrs117767867
geneviewrs117767867
scholarrs117767867
googlers117767867
pharmgkbrs117767867
gwascentralrs117767867
openSNPrs117767867
23andMers117767867
23andMe allrs117767867
SNP Nexus

SNPshotrs117767867
SNPdbers117767867
MSV3drs117767867
GWAS Ctlgrs117767867
GMAF0.07071
Max Magnitude1.5
rs117767867 is a SNP in the SLC16A11 gene on chromosome 17.

This SNP, rs117767867 is considered the tag SNP for a haplotype consisting of 4 missense variants identified as relatively common in the Native American population and having introgressed into modern humans via admixture with Neanderthals. The other 3 missense variants are rs13342692, rs75418188, and rs75493593. This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.10.1038/nature12828