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rs11833579

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A)
(A;G)
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position666033
GeneNINJ2
is asnp
is mentioned by
dbSNPrs11833579
ebirs11833579
HLIrs11833579
Exacrs11833579
Varsomers11833579
Maprs11833579
PheGenIrs11833579
hapmaprs11833579
1000 genomesrs11833579
hgdprs11833579
ensemblrs11833579
gopubmedrs11833579
geneviewrs11833579
scholarrs11833579
googlers11833579
pharmgkbrs11833579
gwascentralrs11833579
openSNPrs11833579
23andMers11833579
23andMe allrs11833579
SNP Nexus

SNPshotrs11833579
SNPdbers11833579
MSV3drs11833579
GWAS Ctlgrs11833579
GMAF0.281
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs11833579 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs12425791.

Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. 10.1056/NEJMoa0900094

Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.[1]

OMIM601367
Desc
Variant
Relatedalso


[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population


[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population


[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia


[PMID 22212150OA-icon.png] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan


[PMID 22429733OA-icon.png] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions


[PMID 19369658OA-icon.png] Genomewide association studies of stroke.


[PMID 20448654] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.


[PMID 20957003] [Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district].


[PMID 21376321] No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.


[PMID 22297388] Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.


[PMID 23270316] Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis


[PMID 22938733] Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population


[PMID 22795341] The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.


[PMID 25096477] Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis


[PMID 26312640] Impact of chromosome 12p13 variants on ischemic stroke risk


[PMID 26687183] A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.