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rs11868035

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.19x increased risk for T2D
(A;G) 1.19x increased risk for T2D
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome17
Position17811787
GeneRAI1, SREBF1
is asnp
is mentioned by
dbSNPrs11868035
ebirs11868035
HLIrs11868035
Exacrs11868035
Varsomers11868035
Maprs11868035
PheGenIrs11868035
hapmaprs11868035
1000 genomesrs11868035
hgdprs11868035
ensemblrs11868035
gopubmedrs11868035
geneviewrs11868035
scholarrs11868035
googlers11868035
pharmgkbrs11868035
gwascentralrs11868035
openSNPrs11868035
23andMers11868035
23andMe allrs11868035
SNP Nexus

SNPshotrs11868035
SNPdbers11868035
MSV3drs11868035
GWAS Ctlgrs11868035
GMAF0.4692
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs11868035 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, rs11868035(A), in the orientation as in dbSNP. [PMID 18192539]

[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)

This SNP rs11868035 and rs1057217 are associated with increased risk of schizophrenia in German and Scandinavian samples. [PMID 18936756]

This SNP and rs6812193 are reported to affect risk of Parkinson's disease. [PMID 21738487OA-icon.png] plos

Neighborrs2297508
Distance216



[PMID 22531747] Association study between two novel single nucleotide polymorphisms and sporadic Parkinson's disease in Chinese Han population


[PMID 22678801] [Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]

[PMID 17019602OA-icon.png] Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.


GET Evidence
rs11868035
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.404762
summary



[PMID 24152445OA-icon.png] Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway