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rs2297508

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) normal
(C;G) 1.08x increased risk for T2D
(G;G) 1.08x increased risk for T2D
ReferenceGRCh38 38.1/141
Chromosome17
Position17812003
GeneLOC100289553, SREBF1
is asnp
is mentioned by
dbSNPrs2297508
ebirs2297508
HLIrs2297508
Exacrs2297508
Varsomers2297508
Maprs2297508
PheGenIrs2297508
hapmaprs2297508
1000 genomesrs2297508
hgdprs2297508
ensemblrs2297508
gopubmedrs2297508
geneviewrs2297508
scholarrs2297508
googlers2297508
pharmgkbrs2297508
gwascentralrs2297508
openSNPrs2297508
23andMers2297508
23andMe allrs2297508
SNP Nexus

SNPshotrs2297508
SNPdbers2297508
MSV3drs2297508
GWAS Ctlgrs2297508
GMAF0.4578
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs2297508 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, rs2297508(C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001).[PMID 18192539]

[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)

Neighborrs11868035
Distance216


[PMID 21178094] A Two-Step Association Study Identifies CAV2 rs2270188 Single Nucleotide Polymorphism Interaction with Fat Intake in Type 2 Diabetes Risk


[PMID 21609284] Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth


[PMID 22678801] [Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]

[PMID 17160088] The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population.


[PMID 24152445OA-icon.png] Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway


[PMID 24614076OA-icon.png] Single Nucleotide Polymorphism of SREBF-1 Gene Associated with an Increased Risk of Endometrial Cancer in Chinese Women