| Geno
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Mag
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Summary
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| (T;T)
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0
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common genotype
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10.1016/j.celrep.2015.09.065 Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. "We observed that the rs12291063 CC genotype was associated with lower expressions of BDNF transcripts ... and higher BMI and adiposity .... Our in vivo and clinical findings indicate that BDNF rs12291063, which had an MAF of ∼30% within our Hispanic and African-American cohorts, could play an important role in the pathogenesis of obesity in these populations. Mechanistically, our data suggest that diminished binding of hnRNPD0B at the rs12291063 locus in individuals with the CC genotype could cause decreased BDNF mRNA expression and protein concentrations within the hypothalamus, potentially leading to excessive energy intake and weight gain."
