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rs17300539

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) if obese, dieting more effective
(A;G) if obese, dieting more effective
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome3
Position186841671
GeneADIPOQ
is asnp
is mentioned by
dbSNPrs17300539
ebirs17300539
HLIrs17300539
Exacrs17300539
Varsomers17300539
Maprs17300539
PheGenIrs17300539
hapmaprs17300539
1000 genomesrs17300539
hgdprs17300539
ensemblrs17300539
gopubmedrs17300539
geneviewrs17300539
scholarrs17300539
googlers17300539
pharmgkbrs17300539
gwascentralrs17300539
openSNPrs17300539
23andMers17300539
23andMe allrs17300539
SNP Nexus

SNPshotrs17300539
SNPdbers17300539
MSV3drs17300539
GWAS Ctlgrs17300539
GMAF0.03994
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs17300539, also known as -11391 G/A, is a SNP in the promoter of the adiponectin ADIPOQ gene.

A small study of 180 Spanish patients with obesity concluded that rs17300539(G;G) individuals are at increased risk of insulin resistance and MetS complications compared to carriers of an (A) allele. The rs17300539(A) allele confered protection from weight regain, particularly at 32-60 weeks after the low-calorie dietary intervention, when improvement in GG subjects had disappeared [PMID 18949681]

[PMID 18776141OA-icon.png] adiponectin levels and risk of diabetes rs17300539 P(n) = 2.6 x 10(-8) and rs822387 (P(n) = 3.8 x 10(-5)


[PMID 19893502] Early Detrimental Metabolic Outcomes of rs17300539-A Allele of ADIPOQ Gene Despite Higher Adiponectinemia


[PMID 20067957OA-icon.png] The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits


[PMID 19761474OA-icon.png] Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 21208676] Association of the adiponectin rs266729 C>G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort

OMIM612556
Desc
Variant
Relatedalso


[PMID 20395949] Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study


[PMID 21562092OA-icon.png] Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome


[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects


[PMID 18498634OA-icon.png] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.


[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.


[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.


[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.


[PMID 18974768] The adiponectin rs17300539 G>A variant and nephropathy risk.


[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.


[PMID 19056609OA-icon.png] Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.


[PMID 19074982OA-icon.png] Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.


[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.


[PMID 19543786] ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity.


[PMID 20667095OA-icon.png] Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.


[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.


[PMID 21229348] Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study.


[PMID 21377959] [Association between single nucleotide polymorphisms (SNPs) at the promoter of adiponectin gene and essential hypertension in Chinese Korean and Han of Yanbian region].


[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.


[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.


[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study


[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals


[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia


[PMID 23845780] Association of Adiponectin Promoter Variants With Traits and Clusters of Metabolic Syndrome in Arabs: Family-based study


[PMID 24055485] Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population


[PMID 23102667OA-icon.png] Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study.


[PMID 23274890OA-icon.png] Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.


[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis


[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].


[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.