|(A;A)||0||Two copies of the Thr allele in the FABP2 is associated with significantly increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.|
|(A;G)||A single copy of the Thr allele associated with a moderately increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.|
|(G;G)||This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.|
The derived allele at SNP (A54T), rs1799883, in FABP2 increases strongly with latitude (p < 0.01) [PMID 18282109]
and may influence weight management
|Disease||FATTY ACID-BINDING PROTEIN|
|CLNDBN||FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF|
|CLNSRC||OMIM Allelic Variant|
[PMID 16175505] Identification of four gene variants associated with myocardial infarction.
[PMID 18506375] Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
[PMID 19288030] Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 20413122] Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial.
[PMID 20416077] Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23826253] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study
[PMID 22038464] Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.