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rs1799883

From SNPedia

Orientationminus
Stabilizedplus
Geno Mag Summary
(A;A) 0 Two copies of the Thr allele in the FABP2 is associated with significantly increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.
(A;G) A single copy of the Thr allele associated with a moderately increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.
(G;G) This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.
ReferenceGRCh38 38.1/141
Chromosome4
Position119320747
GeneFABP2
is asnp
is mentioned by
dbSNPrs1799883
ebirs1799883
HLIrs1799883
Exacrs1799883
Varsomers1799883
Maprs1799883
PheGenIrs1799883
hapmaprs1799883
1000 genomesrs1799883
hgdprs1799883
ensemblrs1799883
gopubmedrs1799883
geneviewrs1799883
scholarrs1799883
googlers1799883
pharmgkbrs1799883
gwascentralrs1799883
openSNPrs1799883
23andMers1799883
23andMe allrs1799883
SNP Nexus

SNPshotrs1799883
SNPdbers1799883
MSV3drs1799883
GWAS Ctlgrs1799883
GMAF0.2521
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1799883 Fatty acid binding protein 2 (FABP2) Ala54Thr;

The derived allele at SNP (A54T), rs1799883, in FABP2 increases strongly with latitude (p < 0.01) [PMID 18282109OA-icon.png]

and may influence weight management

OMIM134640
Desc
Variant0001
Relatedalso


ClinVar
Risk rs1799883(G;G)
Alt rs1799883(G;G)
Reference rs1799883(A;A)
Significance Non-pathogenic
Disease FATTY ACID-BINDING PROTEIN
Variation info
Gene FABP2
CLNDBN FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF
Reversed 1
HGVS NC_000004.11:g.120241902T>C
CLNSRC OMIM Allelic Variant
CLNACC RCV000017958.2,



[PMID 16175505OA-icon.png] Identification of four gene variants associated with myocardial infarction.

[PMID 18506375] Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.

[PMID 19288030] Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.

[PMID 19379518OA-icon.png] Development of a fingerprinting panel using medically relevant polymorphisms.

[PMID 20413122] Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial.

[PMID 20416077OA-icon.png] Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.


GET Evidence
FABP2-T55A
aa_change Thr55Ala
aa_change_short T55A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.749024
summary



[PMID 23826253OA-icon.png] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study


[PMID 22038464] Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.