Have questions? Visit https://www.reddit.com/r/SNPedia

rs2491397

From SNPedia

Orientationplus
Stabilizedplus
Make rs2491397(C;C)
Make rs2491397(C;T)
Make rs2491397(T;T)
ReferenceGRCh38 38.1/141
Chromosome9
Position98442880
GeneGABBR2
is asnp
is mentioned by
dbSNPrs2491397
ebirs2491397
HLIrs2491397
Exacrs2491397
Varsomers2491397
Maprs2491397
PheGenIrs2491397
hapmaprs2491397
1000 genomesrs2491397
hgdprs2491397
ensemblrs2491397
gopubmedrs2491397
geneviewrs2491397
scholarrs2491397
googlers2491397
pharmgkbrs2491397
gwascentralrs2491397
openSNPrs2491397
23andMers2491397
23andMe allrs2491397
SNP Nexus

SNPshotrs2491397
SNPdbers2491397
MSV3drs2491397
GWAS Ctlgrs2491397
GMAF0.3893
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 15759211OA-icon.png] Associated with nicotine Dependence as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.

The risk haplotype varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.[PMID 15759211OA-icon.png]

OMIM607340
DescGAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2
Variant
Relatedalso
OMIM607340
Desc
Variant0001
Relatedalso


ClinVar
Risk rs2491397(T;T)
Alt rs2491397(T;T)
Reference rs2491397(C;C)
Significance Other
Disease Tobacco addiction
Variation info
Gene GABBR2
CLNDBN Tobacco addiction, susceptibility to
Reversed 0
HGVS NC_000009.11:g.101205162C\x3d
CLNSRC ClinVar
CLNACC RCV000003495.1,