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rs3750344

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs3750344(A;G)
Make rs3750344(G;G)
ReferenceGRCh38 38.1/141
Chromosome9
Position98578034
GeneGABBR2
is asnp
is mentioned by
dbSNPrs3750344
ebirs3750344
HLIrs3750344
Exacrs3750344
Varsomers3750344
Maprs3750344
PheGenIrs3750344
hapmaprs3750344
1000 genomesrs3750344
hgdprs3750344
ensemblrs3750344
gopubmedrs3750344
geneviewrs3750344
scholarrs3750344
googlers3750344
pharmgkbrs3750344
gwascentralrs3750344
openSNPrs3750344
23andMers3750344
23andMe allrs3750344
SNP Nexus

SNPshotrs3750344
SNPdbers3750344
MSV3drs3750344
GWAS Ctlgrs3750344
GMAF0.1795
Max Magnitude0
? (A;A) (A;G) (G;G) 28
[PMID 15759211OA-icon.png] Associated with Nicotine Dependence as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.

Interestingly, the risk allele varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.[PMID 15759211OA-icon.png]

OMIM607340
DescGAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2
Variant
Relatedalso
OMIM607340
Desc
Variant0001
Relatedalso
OMIM607340
Desc
Variant0002
Relatedalso
OMIM607340
Desc
Variant0003
Relatedalso
[PMID 19763258OA-icon.png] Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations.


ClinVar
Risk rs3750344(G;G)
Alt rs3750344(G;G)
Reference rs3750344(A;A)
Significance Other
Disease Tobacco addiction
Variation info
Gene GABBR2
CLNDBN Tobacco addiction, susceptibility to
Reversed 1
HGVS NC_000009.11:g.101340316T>C
CLNSRC OMIM Allelic Variant
CLNACC RCV000003495.1,