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From SNPedia

Geno Mag Summary
(C;C) 0 normal
(C;G) 1.8 0.73x decreased risk for colorectal cancer
(G;G) 2 0.73x decreased risk for colorectal cancer
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs266729
23andMe allrs266729
SNP Nexus

GWAS Ctlgrs266729
Max Magnitude2
? (C;C) (C;G) (G;G) 28
rs266729 is a SNP in the adiponectin ADIPOQ gene that may help elucidate correlations between obesity and some types of cancer.

Two case-control studies including colorectal cancer patients and controls were conducted; the first case involving 441 patients and 658 controls, all of Ashkenazi Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls.

rs266729(G) showed decreased colorectal cancer risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.[1]

23andMe blog obesity and colorectal cancer (G;G) 27% lower odds [PMID 18827209OA-icon.png]

[PMID 19264763] Common variation at the Adiponectin locus is not associated with colorectal cancer risk in the United Kingdom

[PMID 19273568] Genetic variation in adipokine genes and risk of colorectal cancer

[PMID 19359061] APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes


[PMID 20516205] Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 21208676] Association of the adiponectin rs266729 C>G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort

[PMID 21248784] Common variation in the adiponectin gene has an effect on systolic blood pressure

[PMID 21397927OA-icon.png] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk

[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer

[PMID 21637408OA-icon.png] A lack of association between adiponectin polymorphisms and coronary artery disease in a Chinese population

[PMID 21829206OA-icon.png] Adiponectin gene and risk of colorectal cancer

[PMID 21960694OA-icon.png] Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer

[PMID 16955209] Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.

[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.

[PMID 17357073OA-icon.png] Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.

[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.

[PMID 18451143OA-icon.png] Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk.

[PMID 18498634OA-icon.png] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

[PMID 18506375] Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.

[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.

[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

[PMID 18765803OA-icon.png] FOXO3A genotype is strongly associated with human longevity.

[PMID 18776141OA-icon.png] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.

[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.

[PMID 19056609OA-icon.png] Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.

[PMID 19074982OA-icon.png] Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.

[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.

[PMID 19324915] Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.

[PMID 19360113OA-icon.png] The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy.

[PMID 19593725OA-icon.png] Association of maternally inherited GNAS alleles with African-American male birth weight.

[PMID 20011104OA-icon.png] A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

[PMID 20032495] Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.

[PMID 20114006] SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study.

[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.

[PMID 20528971] Low plasma adiponectin concentration is associated with myocardial infarction in young individuals.

[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.

[PMID 20580771] Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis.

[PMID 20667095OA-icon.png] Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.

[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.

[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.

[PMID 21073447] Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients.

[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.

[PMID 21474811] Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.

[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.

[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.

[PMID 22023374OA-icon.png] Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-gamma, and retinoid X receptor-alpha genes and type 2 diabetes risk in a Chinese Han population.

[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.

[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.

[PMID 23041553] Genetic association of adipnectin with type 2 diabetes in Jordanian Arab population

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.1875

[PMID 23143890] Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis

[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis

[PMID 23590551OA-icon.png] Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes

[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study

[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals

[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk

[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia

[PMID 23845780] Association of Adiponectin Promoter Variants With Traits and Clusters of Metabolic Syndrome in Arabs: Family-based study

[PMID 23922565OA-icon.png] Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease

[PMID 24055485] Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population

[PMID 24414038OA-icon.png] Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population

[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.

[PMID 23144319] Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.

[PMID 23144325OA-icon.png] P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.

[PMID 25038177OA-icon.png] Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men

[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents

[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis

[PMID 26042596OA-icon.png] Association of Adiponectin Gene Polymorphism with Nonalcoholic Fatty Liver Disease in Taiwanese Patients with Type 2 Diabetes

[PMID 26051417] Association of Adiponectin Gene Polymorphism rs266729 with Type Two Diabetes Mellitus in Iraqi Population. A pilot Study

[PMID 26068642OA-icon.png] Gender difference in adiponectin associated with cardiovascular mortality

[PMID 26192702] ADIPOQ-11377C>G Polymorphism Increases Risk of Adipokine Abnormalities and Child Obesity Regardless of Dietary Intake

[PMID 26329379OA-icon.png] Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer

[PMID 26370001] Obesity-linked diabetes in the Arab world: a review

[PMID 26865047] Association of adiponectin gene polymorphisms and additional gene-gene interaction with nonalcoholic fatty liver disease in the Chinese Han population.

[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.