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rs28399499

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common in complete genomics
Make rs28399499(C;C)
Make rs28399499(C;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position41012316
GeneCYP2B6
is asnp
is mentioned by
dbSNPrs28399499
ebirs28399499
HLIrs28399499
Exacrs28399499
Varsomers28399499
Maprs28399499
PheGenIrs28399499
hapmaprs28399499
1000 genomesrs28399499
hgdprs28399499
ensemblrs28399499
gopubmedrs28399499
geneviewrs28399499
scholarrs28399499
googlers28399499
pharmgkbrs28399499
gwascentralrs28399499
openSNPrs28399499
23andMers28399499
23andMe allrs28399499
SNP Nexus

SNPshotrs28399499
SNPdbers28399499
MSV3drs28399499
GWAS Ctlgrs28399499
GMAF0.0202
Max Magnitude0
? (C;C) (C;T) (T;T) 28




[PMID 21886015] Cytochrome P450 CYP2B6 genotypes and haplotypes in a Colombian population: identification of novel variant CYP2B6 alleles


[PMID 18728241OA-icon.png] Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation.


[PMID 19239339OA-icon.png] Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.


[PMID 19371316OA-icon.png] CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.


[PMID 19659438OA-icon.png] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.


[PMID 23080225OA-icon.png] Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants


GET Evidence
CYP2B6-I328T
aa_change Ile328Thr
aa_change_short I328T
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0212865
summary Elevated plasma levels of efavirenz. Also associated with response to bupropion and nevirapine.



[PMID 22951632OA-icon.png] Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine


[PMID 24080498] Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients


ClinVar
Risk rs28399499(C;C)
Alt rs28399499(C;C)
Reference rs28399499(T;T)
Significance Drug-response
Disease efavirenz response - Metabolism/PK nevirapine response - Other
Variation info
Gene CYP2B6
CLNDBN efavirenz response - Metabolism/PK nevirapine response - Other
Reversed 0
HGVS NC_000019.9:g.41518221T>C
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211262.1, RCV000211386.1,