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CYP2B6

From SNPedia

is agene
is mentioned by
Full namecytochrome P450, family 2, subfamily B, polypeptide 6
EntrezGene1555
PheGenI1555
VariationViewer1555
ClinVarCYP2B6
GeneCardsCYP2B6
dbSNP1555
SADR1555
HugeNav1555
CYPANCcyp2b6
wikipediaCYP2B6
googleCYP2B6
gopubmedCYP2B6
EVSCYP2B6
HEFalMpCYP2B6
MyGene2CYP2B6
23andMeCYP2B6
UniProtP20813
EnsemblENSG00000197408
OMIM123930
# SNPs28
 Max MagnitudeChromosome positionSummary
rs1040395541,003,533
rs104238941,018,248
rs12721646041,009,202
rs12721655041,004,377
rs139801276041,004,303
rs186335453041,004,158
rs2279343041,009,358
rs227934441,009,578
rs2279345041,009,797
rs281864907041,004,015
rs28399497041,009,358
rs28399499041,012,316
rs3211371041,016,810
rs34097093041,012,465
rs34223104040,991,224
rs35303484040,991,441
rs36079186041,007,013
rs371424910041,007,057
rs373489637041,006,968
rs3745274241,006,936
rs480210140,990,556
rs480210441,015,622
rs4803419041,006,887
rs5842503441,009,060
rs726032941,015,733
rs810984841,016,164
rs8192709040,991,369
rs819271941,012,868

The protein encoded by the CYP2B6 gene is the primary metabolizer of a number of drug substrates, such as bupropion, cyclophosphamide, ifosfamide, pethidine, efavirenz, neverapine, ketamine and propofol. [PMID 17073575]

SNPs in CYP2B6 may thus influence the efficacy of such drugs. For example, the effectiveness of bupropion, a commonly used smoking cessation drug, has been reported to vary depending on CYP2B6 genotype.

Mirtazapine concentration is affected by CYP2B6, which could be associated with efficacy [PMID 22926595].

Note that there are over 100 CYP2B6 SNPs known, with numerous complex haplotypes and distinct ethnic frequencies, making CYP2B6 one of the most polymorphic cytochrome p450 genes in humans. [PMID 17638512]