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rs2952768

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 less drug dependence, decreased effectiveness of analgesics
(C;T) 1 slightly less drug dependence, decreased effectiveness of analgesics
(T;T) 1 normal/slightly increased risk of drug dependence, normal effectiveness of analgesics
ReferenceGRCh38 38.1/141
Chromosome2
Position207629510
is asnp
is mentioned by
dbSNPrs2952768
ebirs2952768
HLIrs2952768
Exacrs2952768
Varsomers2952768
Maprs2952768
PheGenIrs2952768
hapmaprs2952768
1000 genomesrs2952768
hgdprs2952768
ensemblrs2952768
gopubmedrs2952768
geneviewrs2952768
scholarrs2952768
googlers2952768
pharmgkbrs2952768
gwascentralrs2952768
openSNPrs2952768
23andMers2952768
23andMe allrs2952768
SNP Nexus

SNPshotrs2952768
SNPdbers2952768
MSV3drs2952768
GWAS Ctlgrs2952768
GMAF0.3581
Max Magnitude1
? (C;C) (C;T) (T;T) 28
Genome-wide association study identifies a potent locus associated with human opioid sensitivity

10.1038/mp.2012.164 rs2952768(C) was associated with more analgesic requirements ... exhibited less vulnerability to severe methamphetamine or alcohol dependence, fewer eating disorders, and a lower ‘Reward Dependence’ score on a personality questionnaire. The (C;C) genotype was significantly associated with the elevated expression of a neighboring gene, CREB1. SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics such as morphine and fentanyl and liability to severe substance dependence. These findings may provide valuable information for the personalized treatment of pain and drug dependence.

Other related opioids include buprenorphine, meperidine and pentazocine.

GWAS snp
PMID [PMID 23183491OA-icon.png]
Trait Opioid sensitivity
Title Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
Risk Allele C
P-val 8E-7
Odds Ratio .29 unit increase


ClinVar
Risk rs2952768(C;C)
Alt rs2952768(C;C)
Reference rs2952768(T;T)
Significance Drug-response
Disease meperidine response - Dosage pentazocine response - Dosage morphine response - Dosage buprenorphine response - Dosage fentanyl response - Dosage opioids response - Dosage
Variation info
Gene
CLNDBN meperidine response - Dosage pentazocine response - Dosage morphine response - Dosage buprenorphine response - Dosage fentanyl response - Dosage opioids response - Dosage
Reversed 0
HGVS NC_000002.11:g.208494234T>C
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211200.1, RCV000211227.1, RCV000211287.1, RCV000211288.1, RCV000211383.1, RCV000211411.1,