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rs363043

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(C;T)
(T;T)
ReferenceGRCh38 38.1/141
Chromosome20
Position10245498
GeneSNAP25
is asnp
is mentioned by
dbSNPrs363043
ebirs363043
HLIrs363043
Exacrs363043
Varsomers363043
Maprs363043
PheGenIrs363043
hapmaprs363043
1000 genomesrs363043
hgdprs363043
ensemblrs363043
gopubmedrs363043
geneviewrs363043
scholarrs363043
googlers363043
pharmgkbrs363043
gwascentralrs363043
openSNPrs363043
23andMers363043
23andMe allrs363043
SNP Nexus

SNPshotrs363043
SNPdbers363043
MSV3drs363043
GWAS Ctlgrs363043
GMAF0.2328
Max Magnitude0
? (C;C) (C;T) (T;T) 28

SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 16801949].

The (T;T) genotype averages several PIQ points higher than the (C;T) genotype, which averages several PIQ points higher than the (C;C) genotype. [PMID 17908175]

For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]


[PMID 21497654] SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.


[PMID 23593184OA-icon.png] DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.


[PMID 25024311] Possible association between SNAP-25 single nucleotide polymorphisms and alterations of categorical fluency and functional MRI parameters in Alzheimer's disease