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rs3758391

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 Normal (worse) aging.
(C;T) 2 Less mental decline with age.
(T;T) 2.4 Increased longevity. Less mental decline with age.
ReferenceGRCh38 38.1/142
Chromosome10
Position67883584
GeneSIRT1
is asnp
is mentioned by
dbSNPrs3758391
ebirs3758391
HLIrs3758391
Exacrs3758391
Varsomers3758391
Maprs3758391
PheGenIrs3758391
hapmaprs3758391
1000 genomesrs3758391
hgdprs3758391
ensemblrs3758391
gopubmedrs3758391
geneviewrs3758391
scholarrs3758391
googlers3758391
pharmgkbrs3758391
gwascentralrs3758391
openSNPrs3758391
23andMers3758391
23andMe allrs3758391
SNP Nexus

SNPshotrs3758391
SNPdbers3758391
MSV3drs3758391
GWAS Ctlgrs3758391
GMAF0.4729
Max Magnitude2.4
? (C;C) (C;T) (T;T) 28
rs3758391, a SNP in the SIRT1 gene, has been reported to potentially have some role in either longevity, or with higher statistical significance, better cognitive function in older individuals. SIRT1 is thought to regulate neuronal metabolism and survival in response to stress, and the equivalent gene in other species influences maximal life span. The study reporting improved cognition for carriers of rs3758391(T) alleles was based on over 1,000 Finnish adults over the age of 85, and a weak trend towards lower cardiovascular disease was also reported for this allele. [PMID 17895433]


[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

[PMID 20633545] SIRT1 variants are associated with aging in a healthy Han Chinese population


[PMID 23450480] [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]


[PMID 27089876] [Common variants in SIRT1 and human longevity in a Chinese population]