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rs3758391(C;C)

From SNPedia

Normal (worse) aging.
Is agenotype
ofrs3758391
GeneSIRT1
Chromosome10
Position67,883,584
mentionedby
Magnitude2
ReputeBad
Geno Mag Summary
(C;C) 2 Normal (worse) aging.
(C;T) 2 Less mental decline with age.
(T;T) 2.4 Increased longevity. Less mental decline with age.

This is the less beneficial version of the SIRT1 longevity gene, which doesn't extend lifespan. It is normal in non-Asians. It has more cognitive decline with age. Taking resveratrol is also believed to increase longevity via the SIRT1 gene, so it might (or might not) be possible to mitigate this with resveratrol supplements or some other SIRT1 activator.