Have questions? Visit https://www.reddit.com/r/SNPedia

rs3783641

From SNPedia

Orientationplus
Stabilizedplus
Make rs3783641(A;A)
Make rs3783641(A;T)
Make rs3783641(T;T)
ReferenceGRCh38 38.1/141
Chromosome14
Position54893421
GeneGCH1
is asnp
is mentioned by
dbSNPrs3783641
ebirs3783641
HLIrs3783641
Exacrs3783641
Varsomers3783641
Maprs3783641
PheGenIrs3783641
hapmaprs3783641
1000 genomesrs3783641
hgdprs3783641
ensemblrs3783641
gopubmedrs3783641
geneviewrs3783641
scholarrs3783641
googlers3783641
pharmgkbrs3783641
gwascentralrs3783641
openSNPrs3783641
23andMers3783641
23andMe allrs3783641
SNP Nexus

SNPshotrs3783641
SNPdbers3783641
MSV3drs3783641
GWAS Ctlgrs3783641
GMAF0.2309
Max Magnitude
? (A;A) (A;T) (T;T) 28
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. A allele associated with higher tolerance to pain.[PMID 17057711]

Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. A allele associated with higher tolerance to pain.[PMID 19081190OA-icon.png]

Do genetic predictors of pain sensitivity associate with persistent widespread pain? A allele associated with higher pain tolerance.[PMID 19775452OA-icon.png]

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, rs10483639(C)-rs3783641(A)-rs8007267(T), associated with lower levels of tetrahydrobiopterin.[PMID 18598896OA-icon.png]


[PMID 17343757OA-icon.png] Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.


[PMID 17363416] Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.


[PMID 19014702OA-icon.png] Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?


[PMID 19751821OA-icon.png] Oxidative risk for atherothrombotic cardiovascular disease.


[PMID 20633294OA-icon.png] Different SNP combinations in the GCH1 gene and use of labor analgesia.


[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.


[PMID 23059057OA-icon.png] A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study


[PMID 22770721] GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder


[PMID 23322459] Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.