|(A;A)||2||1.9x risk for developing restless legs syndrome|
|(A;G)||1.5||Slightly increased risk of developing restless legs syndrome|
|(G;G)||1||Normal risk of developing restless legs syndrome|
Consistent with this finding, another report about rs3923809 links the (G) minor allele to a lower frequency of restless legs syndrome with an overall odds ratio of 0.57 (CI: 0.48-0.68). [PMID 17637780]
Note that 70-80% of all individuals in European populations carry one or two copies of the (A) major allele, yet restless legs syndrome is thought to affect less than 10% of all adults. Therefore, although an individual may be at higher risk based on their genotype, the genotype by itself certainly isn't able to predictably cause restless legs syndrome.
The association between rs3923809 and RLS has been replicated in three European populations, and shows the most consistent effect across populations of several SNPs studied.[PMID 19279021]
The results of a 2013 study of Korean patients suggest that the role of BTBD9 in the pathogenesis of restless legs syndrome is more universal across populations than previously reported and more efforts should be focused on the role of epistasis in the genetic architecture of restless legs syndrome. A significant association was found for rs3923809 and rs9296249 in BTBD9. [PMID 24293752]
|Condition||Restless legs syndrome|
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 24293752] Association of restless legs syndrome variants in Korean patients with restless legs syndrome.
[PMID 23361623] The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia
[PMID 25142570] Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD
[PMID 26703954] Prevalence and determinants of periodic limb movements in the general population.