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rs4290270

From SNPedia

Orientationplus
Stabilizedplus
Make rs4290270(A;A)
Make rs4290270(A;T)
Make rs4290270(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position72022455
GeneTPH2
is asnp
is mentioned by
dbSNPrs4290270
ebirs4290270
HLIrs4290270
Exacrs4290270
Varsomers4290270
Maprs4290270
PheGenIrs4290270
hapmaprs4290270
1000 genomesrs4290270
hgdprs4290270
ensemblrs4290270
gopubmedrs4290270
geneviewrs4290270
scholarrs4290270
googlers4290270
pharmgkbrs4290270
gwascentralrs4290270
openSNPrs4290270
23andMers4290270
23andMe allrs4290270
SNP Nexus

SNPshotrs4290270
SNPdbers4290270
MSV3drs4290270
GWAS Ctlgrs4290270
GMAF0.4949
Max Magnitude
? (A;A) (A;T) (T;T) 28
Only for Hispanics, individuals who have a genoset composed of rs1799913(C;C) and rs4290270(T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012).[PMID 18181017]


[PMID 19352219] Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder

[PMID 19763617] Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease


[PMID 21620479] Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population


[PMID 17167340] Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees.


[PMID 17453063] Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.


[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.


[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 20126463OA-icon.png] Alternative splicing and extensive RNA editing of human TPH2 transcripts.


[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21937687] Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.


[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.


[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.


[PMID 26028568] Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population


[PMID 26057341] Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population


[PMID 26232682] Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms