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rs4324715

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.2 >1.5x increased testicular cancer risk for men
(C;T) 1.1 1.5x increased testicular cancer risk for men
(T;T) 1 Normal risk of testicular cancer.
ReferenceGRCh38 38.1/141
Chromosome5
Position142289942
is asnp
is mentioned by
dbSNPrs4324715
ebirs4324715
HLIrs4324715
Exacrs4324715
Varsomers4324715
Maprs4324715
PheGenIrs4324715
hapmaprs4324715
1000 genomesrs4324715
hgdprs4324715
ensemblrs4324715
gopubmedrs4324715
geneviewrs4324715
scholarrs4324715
googlers4324715
pharmgkbrs4324715
gwascentralrs4324715
openSNPrs4324715
23andMers4324715
23andMe allrs4324715
SNP Nexus

SNPshotrs4324715
SNPdbers4324715
MSV3drs4324715
GWAS Ctlgrs4324715
GMAF0.3549
Max Magnitude1.2
? (C;C) (C;T) (T;T) 28
Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 40% per copy of the major (T) allele at rs4324715 and rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [doi|10.1038/ng.393]


[PMID 19483682OA-icon.png] Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.


[PMID 22072546] Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.