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rs5082

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 2.5 saturated fat contributes to obesity, but 0.57 % lower risk for coronary artery disease
(C;T) 0 normal risk
(T;T) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome1
Position161223893
GeneAPOA2
is asnp
is mentioned by
dbSNPrs5082
ebirs5082
HLIrs5082
Exacrs5082
Varsomers5082
Maprs5082
PheGenIrs5082
hapmaprs5082
1000 genomesrs5082
hgdprs5082
ensemblrs5082
gopubmedrs5082
geneviewrs5082
scholarrs5082
googlers5082
pharmgkbrs5082
gwascentralrs5082
openSNPrs5082
23andMers5082
23andMe allrs5082
SNP Nexus

SNPshotrs5082
SNPdbers5082
MSV3drs5082
GWAS Ctlgrs5082
GMAF0.2521
Max Magnitude2.5
? (C;C) (C;T) (T;T) 28
rs5082 is a SNP in the apolipoprotein APOA2 gene, and may influence obesity and heart disease risk.

Individuals homozygous for the -265T>C polymorphism in rs5082, i.e. individuals with the rs5082(C;C) genotype of the Apolipoprotein A-II gene (APOA2) promoter, are associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for obesity in (C;C) individuals compared to rs5082(T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals.[PMID 17446329]

In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients and 498 male controls concluded that rs5082(C;C) individuals were at significantly lower risk for that form of heart disease than rs5082(T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004).[PMID 18179799]

A meta-analysis of several APOA2 SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes.[PMID 19216768OA-icon.png]

[PMID 17709437] An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men.

[PMID 18304332OA-icon.png] No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.

Response to Diet and Exercise


[PMID 24108135OA-icon.png] Apolipoprotein A2 Polymorphism Interacts with Intakes of Dairy Foods to Influence Body Weight in Two U.S. Populations


[PMID 26210798] APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes


[PMID 26590203] Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels