|| saturated fat contributes to obesity, but 0.57 % lower risk for coronary artery disease
|| normal risk
|| normal risk
|?|| (C;C) (C;T) (T;T) ||28|
is a SNP in the apolipoprotein APOA2
gene, and may influence obesity
and heart disease
Individuals homozygous for the -265T>C polymorphism in rs5082, i.e. individuals with the rs5082(C;C) genotype of the Apolipoprotein A-II gene (APOA2) promoter, are associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for obesity in (C;C) individuals compared to rs5082(T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals.[PMID 17446329]
In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients and 498 male controls concluded that rs5082(C;C) individuals were at significantly lower risk for that form of heart disease than rs5082(T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004).[PMID 18179799]
A meta-analysis of several APOA2 SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes.[PMID 19216768]
[PMID 17709437] An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men.
[PMID 18304332] No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.
Response to Diet and Exercise
[PMID 24108135] Apolipoprotein A2 Polymorphism Interacts with Intakes of Dairy Foods to Influence Body Weight in Two U.S. Populations
[PMID 26210798] APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes
[PMID 26590203] Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels